Protein Alignment 5-HT2B and LOC1269968

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_061499186.1
• Gene: LOC1269968 / 1269968
• VectorBaseID: AGAMI1_010361
• Length: 587
• Species: Anopheles gambiae
• Alignment Length: 924
• Identity: 203/924 - (21%)
• Similarity: 313/924 - (33%)
• Gaps: 372/924 - (40%)

  Fly     4 DVYASLGAYNDSGG-DDWSSSEHLVLWEE---DETQRTTANATSRHNQLHVARWNATGNATISAT 64
            |||..:  :.|||. |.:.|::...:..|   :|:....||.|.      :....|:.|.|....
Mosquito    23 DVYDYI--FIDSGSPDSYLSADVGSIGNETFFNESANAFANTTD------LGPVPASINGTADEP 79

  Fly    65 FEDVPFDANNYWALLALVL---VLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLV 126
            ..||     ...|:.:|||   :|.|..||:.|..||..||.||||.||.:.|||:.||.||.||
Mosquito    80 LADV-----IVMAITSLVLGLMILVTVIGNVFVIAAIILERNLQNVANYLVASLAVADLFVACLV 139

  Fly   127 MPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVT 191
            ||||.:..:...:.||.|.|..|...|||.|||||:||..|:.|||.::. .:.:..::|.|||.
Mosquito   140 MPLGAVYEISRGWILGPELCDIWTSCDVLCCTASILHLVAIATDRYWAVT-NIDYIHSRTSRRVF 203

  Fly   192 LKIVFVWLLSIAMSL-PLSLMYSKNHASVLVNGTCQIPDPV-YKLVGSIVCFYIPLGVMLLTYCL 254
            ..|..||..|:.:|| |........:...:....|.:...: |::..:...||:||.|:|:.|..
Mosquito   204 TMIFLVWFASVIVSLAPQFGWKDPEYLQRIEQQKCMVSQNIAYQVFATCCTFYVPLFVILVLYWK 268

  Fly   255 TVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANST 319
            .              .|||.                      ||:.:.||...::
Mosquito   269 I--------------YQTAR----------------------RRIHRRGPKIPAT---------- 287

  Fly   320 DTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSN 384
                          |:||.:|.||                                 |.:..:..
Mosquito   288 --------------PNSSNQEETP---------------------------------KPKSKIRF 305

  Fly   385 HLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNS 449
            ||:.:: ::|.:.|.:.                              |||      :|..||
Mosquito   306 HLKKKF-TNPTKSAVSS------------------------------LGL------VEGNST--- 330

  Fly   450 LASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHN 514
                                                                             
Mosquito   331 ----------------------------------------------------------------- 330

  Fly   515 SLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQS 579
                       .|| .:::|.:|....:|.:|..:|...   .|.....|        .|.|
Mosquito   331 -----------NTV-NTVEDTEDSTANAADRKGLETTFS---GDEGNGTP--------LGNN--- 369

  Fly   580 DYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLT 644
               |:|:|                         ::.||....|.::.        ||..|..:
Mosquito   370 ---QIPTV-------------------------SYEVTHQQLAQAAG--------CSESNNNN-- 396

  Fly   645 SSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTAS 709
               :.|.||.....:|:..|.||       .||:..||   :.:.::|..|
Mosquito   397 ---NPGRTGSAGKTSPSGNGGTL-------PGSTYPVQ---AVHASSPLLP-------------- 434

  Fly   710 VVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTR 774
                  .:|:...::....:.:  .|||...|..::.:.|              ||||  ||.|.
Mosquito   435 ------PQHQHHNAATAAKQPA--GTPTAHLTPGSAGSGL--------------QGAG--GGSTL 475

  Fly   775 TTTSSP----CMLQRQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPF 835
            ...|:|    .:.:|::|:.:                    :.|:||.|.|.::...||:.|.||
Mosquito   476 NIASTPNPQAQVSKRKETLEA--------------------KRERKAAKTLAIITGAFVVCWLPF 520

  Fly   836 FVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAW 900
            |:..||..:|..|.  |:..|..:..||||.:|.:||:.||||:..||||||::|...:.|.:..
Mosquito   521 FLTALLLPLCESCS--INDTVASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRILFGTHRSANYR 583

  Fly   901 RPSRXQTPVKPGKL 914
            |          |||
Mosquito   584 R----------GKL 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	71/197 (36%)
		TM helix 1	75..101	CDD:320433	11/28 (39%)
		TM helix 2	108..134	CDD:320433	15/25 (60%)
		TM helix 3	146..176	CDD:320433	16/29 (55%)
		TM helix 4	188..211	CDD:320433	10/23 (43%)
		TM helix 5	229..258	CDD:320433	8/29 (28%)
		7tm_GPCRs	<799..893	CDD:475119	35/93 (38%)
		TM helix 6	818..840	CDD:410628	8/21 (38%)
		TM helix 7	854..879	CDD:410628	11/24 (46%)
LOC1269968	XP_061499186.1	None