Protein Alignment 5-HT2B and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_061500179.1
• Gene: 5-HT2A / 1269329
• VectorBaseID: AGAMI1_010455
• Length: 825
• Species: Anopheles gambiae
• Alignment Length: 899
• Identity: 207/899 - (23%)
• Similarity: 298/899 - (33%)
• Gaps: 397/899 - (44%)

  Fly    24 EHLVLWEEDETQR-----TTANATSRHNQLHVARWNAT--------GNATISATFEDVPFDANNY 75
            |.:..|...|.:.     |..|....|....:|.||.|        |..|....:|
Mosquito   257 EPIQCWMNVELRNALVSPTWLNGAEHHAVAALAGWNQTQLLGELPAGGDTAPGRYE--------- 312

  Fly    76 WALLALVL-VLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGYF 139
            |:.|.::| :.....||||||||:|.:|:|||||||||:||||.||:|::.|||||.:....||:
Mosquito   313 WSFLFVILFIFAGGLGNILVCLAVALDRKLQNVTNYFLLSLAIADLLVSLFVMPLGAIPGFLGYW 377

  Fly   140 PLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAM 204
            |.|...|..::..|||.|:|||:|:|.||:.|||.:|.|:....:.|:|...:||..||||::.:
Mosquito   378 PFGVTWCNIYVTCDVLACSASILHMCFISLGRYLGIRNPLGSRHHSTKRLTGIKIALVWLLAMLV 442

  Fly   205 SLPLSLMYSKNHASVLVN-GTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGG 268
            |..::::...|..:::.. ..|.|.:..:.:.||:|.||||:.:|::||.|||:||.::.:
Mosquito   443 SSSITVLGMINQNNIMPGPNECVINNRAFFVFGSLVAFYIPMVMMVVTYALTVQLLRKKAR---- 503

  Fly   269 GQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWL 333
                          :|.|.|..|   .:|||   |...|||   .||.||
Mosquito   504 --------------FLEQHPEGE---LFRRL---GGRLASS---KHSNNS--------------- 530

  Fly   334 PDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYA 398
                                          :|..||::..:....:|:::|:.|..|
Mosquito   531 ------------------------------QSDGSSTSNKAVEMRKFTVNNNKQPAY-------- 557

  Fly   399 ATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGT 463
                                      |:|.:               |..:||.|...|
Mosquito   558 --------------------------GQHDS---------------SPPSSLPSVAAG------- 574

  Fly   464 LSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTV 528
                                                             |::||
Mosquito   575 -------------------------------------------------HSALP----------- 579

  Fly   529 QESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYF 593
                                                                             
Mosquito   580 ----------------------------------------------------------------- 579

  Fly   594 GDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGA 658
                                :|...||.......|.|              ||:.
Mosquito   580 --------------------WRWHGTTAGTGKMDSRM--------------SSIK---------- 600

  Fly   659 APATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGS 723
                 ||...||..::.|.:.|:....|..:...||..|                ||.....|..
Mosquito   601 -----GSMSHPHLGYSNGGNRTMAGKRSRTVCDQGTQTP----------------DSIERETRRQ 644

  Fly   724 SFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQT 788
            .|...|..|...||...                   |.|.:   ..|.|.||..|:
Mosquito   645 KFCSFRIHLNSVPTPAI-------------------NFNLK---FLGSKKRTNLSA--------- 678

  Fly   789 VRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERIS 853
                                ..:..|||||||||:||||||..|:|||:||::  ..|..|.::.
Mosquito   679 --------------------NAVATEQKATKVLGLVFFTFVFCWAPFFILNII--FAAWPEAKVP 721

  Fly   854 HWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWRPSRXQT 907
            ..:..:..||||.||.:|||.||||||.||.||.::|.||...:.  ||.|.::
Mosquito   722 ERIVSICLWLGYVSSTINPIIYTIFNKTFRAAFIRLLRCRCERSG--RPPRYRS 773

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	82/194 (42%)
		TM helix 1	75..101	CDD:320433	12/26 (46%)
		TM helix 2	108..134	CDD:320433	17/25 (68%)
		TM helix 3	146..176	CDD:320433	15/29 (52%)
		TM helix 4	188..211	CDD:320433	8/22 (36%)
		TM helix 5	229..258	CDD:320433	13/28 (46%)
		7tm_GPCRs	<799..893	CDD:475119	43/93 (46%)
		TM helix 6	818..840	CDD:410628	16/21 (76%)
		TM helix 7	854..879	CDD:410628	12/24 (50%)
5-HT2A	XP_061500179.1	None