DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and Adra1a

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_038489.2 Gene:Adra1a / 11549 MGIID:104773 Length:466 Species:Mus musculus


Alignment Length:482 Identity:119/482 - (24%)
Similarity:192/482 - (39%) Gaps:130/482 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 NATISATFEDVPFDANNYWALLALV----LVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAIT 118
            ||:..:.....|...|...|:|..|    |::....|||||.|::|..|.|.:||:|::::||:.
Mouse     7 NASEGSNCTHPPAQVNISKAILLGVILGGLIIFGVLGNILVILSVACHRHLHSVTHYYIVNLAVA 71

  Fly   119 DLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGR 183
            ||::...|:|...:..:.||:..|...|..|..:|||.||||||.||.||:|||:.:.||:|:..
Mouse    72 DLLLTSTVLPFSAIFEILGYWAFGRVFCNIWAAVDVLCCTASIMGLCIISIDRYIGVSYPLRYPT 136

  Fly   184 NKTRRRVTLKIVFVWLLSIAMSL-PLSLMYSKNHASVLVNGTCQI-PDPVYKLVGSIVCFYIPLG 246
            ..|:||....::.||.||:.:|: ||   :.....:......||| .:|.|.|..::..||:||.
Mouse   137 IVTQRRGVRALLCVWALSLVISIGPL---FGWRQQAPEDETICQINEEPGYVLFSALGSFYVPLT 198

  Fly   247 VMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVL 311
            ::|:.||....:..|:.:.|..|.:|                                       
Mouse   199 IILVMYCRVYVVAKRESRGLKSGLKT--------------------------------------- 224

  Fly   312 HAHSANSTDTDLSTLDNHELWLPD-----SSIKEPTPTTMTALHQFGAEMLKLSRGLES------ 365
                 :.:|::..||..|...:|.     ||.|..|        .|...:||.||..::      
Mouse   225 -----DKSDSEQVTLRIHRKNVPAEGSGVSSAKNKT--------HFSVRLLKFSREKKAAKTLGI 276

  Fly   366 -----------------VASSSTTGSPTKSEFSLSNHL--------QLQYPSSPQRYAATHQ--- 402
                             :.|......|.::.|.:...|        .:.||.|.|.:....|   
Mouse   277 VVGCFVLCWLPFFLVMPIGSFFPNFKPPETVFKIVFWLGYLNSCINPIIYPCSSQEFKKAFQNVL 341

  Fly   403 --------QSHHH--NHQQHPAGVYHQQASPKGRH----------GTTVLGLSTTTLGIERESTR 447
                    ||..|  .:..||     ...:.:|:|          |.|...:|.|. |:......
Mouse   342 RIQCLRRRQSSKHALGYTLHP-----PSQAVEGQHRGMVRIPVGSGETFYKISKTD-GVREWKFF 400

  Fly   448 NSL--ASSR--MGGEQSDGTLSQLSQR 470
            :|:  .|:|  |..:||..|.:::..:
Mouse   401 SSMPQGSARITMPKDQSACTTARVRSK 427

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 70/198 (35%)
TM helix 1 75..101 CDD:320433 11/29 (38%)
TM helix 2 108..134 CDD:320433 8/25 (32%)
TM helix 3 146..176 CDD:320433 18/29 (62%)
TM helix 4 188..211 CDD:320433 9/23 (39%)
TM helix 5 229..258 CDD:320433 10/28 (36%)
7tm_GPCRs <799..893 CDD:475119
TM helix 6 818..840 CDD:410628
TM helix 7 854..879 CDD:410628
Adra1aNP_038489.2 7tmA_alpha1A_AR 27..337 CDD:320448 94/364 (26%)
TM helix 1 28..54 CDD:320448 10/25 (40%)
TM helix 2 61..87 CDD:320448 8/25 (32%)
TM helix 3 99..129 CDD:320448 18/29 (62%)
TM helix 4 141..164 CDD:320448 9/25 (36%)
TM helix 5 181..210 CDD:320448 10/28 (36%)
TM helix 6 265..295 CDD:320448 2/29 (7%)
TM helix 7 305..330 CDD:320448 4/24 (17%)
Nuclear localization signal. /evidence=ECO:0000250 334..349 1/14 (7%)
Blue background indicates that the domain is not in the aligned region.

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