Protein Alignment 5-HT2B and htr2c

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_017951833.1
• Gene: htr2c / 100496012
• XenbaseID: XB-GENE-967634
• Length: 475
• Species: Xenopus tropicalis
• Alignment Length: 942
• Identity: 171/942 - (18%)
• Similarity: 279/942 - (29%)
• Gaps: 530/942 - (56%)

  Fly    37 TTANAT-----SRHNQLHVARWNATGNATISATF-EDVPFDAN-------------NYWALLALV 82
            ||.:.|     |.||.|  ..|:...|.|::.:. ...|.:|:             |:.|||.|:
 Frog    14 TTVSITRSVDISFHNGL--MAWHVNNNVTLNQSMPTSAPANASEEEKLSHESLADKNWSALLTLI 76

  Fly    83 LVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGY-FPLGSEHC 146
            :::.|..|||||.:|::.|::|||.||:||||||:.|::|.:||||:.::|::..| :||..:.|
 Frog    77 IIILTIGGNILVIMAVSLEKKLQNATNFFLMSLAVADMLVGILVMPVSLVTILYDYAWPLPRKLC 141

  Fly   147 LTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLM 211
            ..||.|||||.||||||||.||:|||:::|.|:...|..:|.:..:||..||.:||.:|:|:.::
 Frog   142 PIWISLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMMKIAAVWTISIGISMPVPVI 206

  Fly   212 YSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAAT 276
            ..::.:.|.||.:|.:.|..:.|:||.|.|:|||.:|:.|||||:::|.:|
 Frog   207 GLQDDSRVFVNSSCVLNDENFVLLGSFVAFFIPLIIMVFTYCLTIQVLQKQ-------------- 257

  Fly   277 PGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEP 341
                                                                             
 Frog   258 ----------------------------------------------------------------- 257

  Fly   342 TPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHH 406
                                                                             
 Frog   258 ----------------------------------------------------------------- 257

  Fly   407 HNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRL 471
                   |.|:..:..|
 Frog   258 -------ATVFMYEEVP------------------------------------------------ 267

  Fly   472 RAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDD 536
                |:||:|
 Frog   268 ----KQRRSS------------------------------------------------------- 273

  Fly   537 DEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNC 601
                                                                          .||
 Frog   274 --------------------------------------------------------------VNC 276

  Fly   602 VKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGST 666
            :|                                    |::.|.::                 |.
 Frog   277 LK------------------------------------KENNTENI-----------------SM 288

  Fly   667 LSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTS 731
            :..|.|
 Frog   289 IQNHEA----------------------------------------------------------- 294

  Fly   732 LLLTPTKTATTSNSSTPLRRSATLRSHQN--MNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHS 794
                                    .||.|  :|.:||                |.|:.|::|
 Frog   295 ------------------------ASHLNSPINKEGA----------------LFRKGTMQS--- 316

  Fly   795 RNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAE-CEERISHWVFD 858
                            |..|::|:||||:|||.|:|:|.|||:.|::..:|.| |:..:...:.:
 Frog   317 ----------------INNERRASKVLGIVFFLFLIMWCPFFITNIMSVLCKEACDNELMVELLN 365

  Fly   859 VVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWRPSRXQ-------TPVKPGKLKT 916
            |..|:||.||.:||:.||:||:.:|:||...:.|:|.::......: |       |.:....|..
 Frog   366 VFVWVGYVSSGINPLVYTLFNRTYRRAFASYIRCQYYNSKKTMLQQNQCQHNATSTAMYGKDLNL 430

  Fly   917 NTHK----CASVDFQDSTAPVR---GVLKRSV 941
            |:::    ..|||..::...:.   |:.:.|:
 Frog   431 NSYRNGNELTSVDMDETEEAIEMQPGISELSI 462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	88/193 (46%)
		TM helix 1	75..101	CDD:320433	11/25 (44%)
		TM helix 2	108..134	CDD:320433	14/25 (56%)
		TM helix 3	146..176	CDD:320433	21/29 (72%)
		TM helix 4	188..211	CDD:320433	8/22 (36%)
		TM helix 5	229..258	CDD:320433	15/28 (54%)
		7tm_GPCRs	<799..893	CDD:475119	35/94 (37%)
		TM helix 6	818..840	CDD:410628	13/21 (62%)
		TM helix 7	854..879	CDD:410628	10/24 (42%)
htr2c	XP_017951833.1	7tmA_5-HT2C	68..399	CDD:341346	148/821 (18%)
		TM helix 1	69..95	CDD:341346	11/25 (44%)
		TM helix 2	102..128	CDD:341346	14/25 (56%)
		TM helix 3	141..171	CDD:341346	21/29 (72%)
		TM helix 4	183..206	CDD:341346	8/22 (36%)
		TM helix 5	224..253	CDD:341346	15/28 (54%)
		TM helix 6	318..348	CDD:341346	16/29 (55%)
		TM helix 7	361..386	CDD:341346	10/24 (42%)