DRSC/TRiP Functional Genomics Resources

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Protein Alignment 5-HT2B and drd4

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:XP_002937535.2 Gene:drd4 / 100486482 XenbaseID:XB-GENE-990215 Length:414 Species:Xenopus tropicalis


Alignment Length:885 Identity:145/885 - (16%)
Similarity:240/885 - (27%) Gaps:505/885 - (57%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 LWEEDETQRTTANATSRHNQLH------VARW----------NATGNATISATFEDVPFDANNYW 76
            |...|.|:|.:.: .:.|::.|      ...|          |.|.::.:...:        |:.
 Frog     9 LASRDNTRRRSLD-KAEHSRYHSVFGDTEGHWGGGAMVHNISNHTSHSAVDPHY--------NFL 64

  Fly    77 ALL-ALVLVLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILT-LVKGYF 139
            ||: ..:|::....||:||||::..|:.|:..||||::|||:.||::||||:||.:.| .|.|.:
 Frog    65 ALVFGFILIVCIICGNVLVCLSVCTEKALKTTTNYFIVSLAVADLLLAVLVLPLYVYTEFVGGVW 129

  Fly   140 PLGSEHCLTWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAM 204
            .|....|...:.:||:.|||||.:||.|||||::::..|:.:.|.:...|....|...|:.:.|:
 Frog   130 TLSLVLCDVLMTMDVMLCTASIFNLCAISVDRFIAVSIPLNYNRRQVDNRQLFLISTTWIFAFAV 194

  Fly   205 SLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGG 269
            :.|  :::..|:.:......|::.|..|.:..|:..|:||..:||:.||                
 Frog   195 ASP--VIFGLNNVADRDPTMCKLEDNNYIVYSSVCSFFIPCPIMLVLYC---------------- 241

  Fly   270 QQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLP 334
                                                                             
 Frog   242 ----------------------------------------------------------------- 241

  Fly   335 DSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAA 399
                                                                             
 Frog   242 ----------------------------------------------------------------- 241

  Fly   400 THQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIER-ESTRNSLASSRMGGEQSDGT 463
                           .::|                     |:.: |.||.:...|.|.       
 Frog   242 ---------------AMFH---------------------GLRKWEETRKTKLRSHMS------- 263

  Fly   464 LSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTV 528
                                 ||                                          
 Frog   264 ---------------------PG------------------------------------------ 265

  Fly   529 QESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYF 593
                                            |.|||                        ||  
 Frog   266 --------------------------------LKPPQ------------------------CP-- 272

  Fly   594 GDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGA 658
                                      ...:..||::                             
 Frog   273 --------------------------ALLLDRSPTD----------------------------- 282

  Fly   659 APATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGS 723
                  |.|...:.::||.                  ||..:           ::..:.|     
 Frog   283 ------SKLDELNLYDQGD------------------CPFPK-----------SYVDNGH----- 307

  Fly   724 SFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQT 788
               |::|.                         ::.::.|           :|...|   :|:| 
 Frog   308 ---GIQTV-------------------------AYPHLKY-----------STNMEP---ERKQ- 329

  Fly   789 VRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAEC---EE 850
                           :..:||    |:||.:||.||...|:..|:||||:::...:|..|   |:
 Frog   330 ---------------AKINGR----ERKAMRVLPVVVGAFLFCWTPFFVVHITRALCESCYIPEQ 375

  Fly   851 RISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVL 890
            .||     :||||||.:|.:||:.|||||..||..|:|||
 Frog   376 LIS-----IVTWLGYVNSALNPVIYTIFNTEFRNYFRKVL 410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 65/194 (34%)
TM helix 1 75..101 CDD:320433 9/26 (35%)
TM helix 2 108..134 CDD:320433 16/26 (62%)
TM helix 3 146..176 CDD:320433 15/29 (52%)
TM helix 4 188..211 CDD:320433 5/22 (23%)
TM helix 5 229..258 CDD:320433 10/28 (36%)
7tm_GPCRs <799..893 CDD:475119 40/95 (42%)
TM helix 6 818..840 CDD:410628 10/21 (48%)
TM helix 7 854..879 CDD:410628 12/24 (50%)
drd4XP_002937535.2 7tmA_D4_dopamine_R 63..406 CDD:320434 131/816 (16%)
TM helix 1 64..90 CDD:320434 9/25 (36%)
TM helix 2 97..123 CDD:320434 15/25 (60%)
TM helix 3 136..166 CDD:320434 15/29 (52%)
TM helix 4 178..201 CDD:320434 5/24 (21%)
TM helix 5 217..246 CDD:320434 11/210 (5%)
TM helix 6 334..364 CDD:320434 15/33 (45%)
TM helix 7 374..399 CDD:320434 15/29 (52%)

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