DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment 5-HT2B and htr1aa

DIOPT Version :10

Sequence 1:NP_001262373.1 Gene:5-HT2B / 41017 FlyBaseID:FBgn0261929 Length:947 Species:Drosophila melanogaster
Sequence 2:NP_001116793.1 Gene:htr1aa / 100001828 ZFINID:ZDB-GENE-071203-1 Length:398 Species:Danio rerio


Alignment Length:862 Identity:143/862 - (16%)
Similarity:219/862 - (25%) Gaps:481/862 - (55%)


- Green bases have known domain annotations that are detailed below.


  Fly    43 SRHNQLHVARWNATGNATISATFEDVPFDANNYWALLALVLVLGTAAGNILVCLAIAWERRLQNV 107
            |.:|......|  :||||   :..:|........:|....|:|....||..|..|||.||.||||
Zfish     3 SYNNTTESQDW--SGNAT---SVSEVALSYQIIGSLFLAALILFAILGNACVIAAIALERSLQNV 62

  Fly   108 TNYFLMSLAITDLMVAVLVMPLGILTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVDRY 172
            .||.:.|||:|||||:|||:|:..|..|...:.||.|.|..:|.||||.||:||:|||.|::|||
Zfish    63 ANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQEMCDIFISLDVLCCTSSILHLCAIALDRY 127

  Fly   173 LSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGS 237
            .::..|:.:...:|.||..:.|...||:..::|:|..|.:.|.......:......|..|.:..:
Zfish   128 WAITDPIDYVNKRTPRRAAILISLTWLIGFSISIPPMLGWRKPEDRADPDACTISQDHGYTIYST 192

  Fly   238 IVCFYIPLGVMLLTY-------CLTVRLLARQRQNLGGGQQTAAATPGW----ASGWLGQAPALE 291
            ...|||||.:||:.|       ...:|...::.:......:..|.:|..    |:|.:|:     
Zfish   193 FGAFYIPLILMLVLYGRIFRAARFRIRKTVKKTEKAKIADKCLAVSPALFPRKANGEVGK----- 252

  Fly   292 RRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQFGAEM 356
               ||||.::|            .||.                                      
Zfish   253 ---TWRRSVEP------------CANG-------------------------------------- 264

  Fly   357 LKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSPQRYAATHQQSHHHNHQQHPAGVYHQQA 421
                                                                             
Zfish   265 ----------------------------------------------------------------- 264

  Fly   422 SPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQSDGTLSQLSQRLRAYKKRRRASSAVPG 486
                                                                             
Zfish   265 ----------------------------------------------------------------- 264

  Fly   487 REKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPRHTTVQESLDDDDDEEEESAQQKDQQTK 551
                                                        :|.:.||.|            
Zfish   265 --------------------------------------------ALKNSDDGE------------ 273

  Fly   552 SKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCTCPYFGDRPLQNCVKSAEVKIISSAFRV 616
                                                                         :|.:
Zfish   274 -------------------------------------------------------------SFEI 277

  Fly   617 TTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGGPAGAAPATVGSTLSPHSAHNQGSSLTV 681
            |                                                              .|
Zfish   278 T--------------------------------------------------------------EV 280

  Fly   682 QSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHRRRGSSFGGVRTSLLLTPTKTATTSNSS 746
            ||....:|:.|..|                                                   
Zfish   281 QSISKNHLSLPNNP--------------------------------------------------- 294

  Fly   747 TPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQRQQTVRSHHSRNSSVISRNSSRHGRII 811
                                            .||...|.:  ::..::....::|         
Zfish   295 --------------------------------QPCFENRNE--KNTEAKRKVALAR--------- 316

  Fly   812 RLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVCAECEERISHWVFDVVTWLGYASSMVNPIFYT 876
              |:|..|.||::..||:..|.|||::.|:...|.:|  .:..|:..|:.||||::|::||:.|.
Zfish   317 --ERKTVKTLGIIMGTFIFCWLPFFIVALVLPFCQDC--FMPEWLGAVINWLGYSNSLLNPVIYA 377

  Fly   877 IFNKVFRQAFKKVLLCR 893
            .|||.|:.||||:|.|:
Zfish   378 YFNKDFQNAFKKILKCK 394

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
5-HT2BNP_001262373.1 7tmA_5-HT2_insect-like 74..>267 CDD:320433 73/199 (37%)
TM helix 1 75..101 CDD:320433 9/25 (36%)
TM helix 2 108..134 CDD:320433 15/25 (60%)
TM helix 3 146..176 CDD:320433 17/29 (59%)
TM helix 4 188..211 CDD:320433 7/22 (32%)
TM helix 5 229..258 CDD:320433 10/35 (29%)
7tm_GPCRs <799..893 CDD:475119 34/93 (37%)
TM helix 6 818..840 CDD:410628 9/21 (43%)
TM helix 7 854..879 CDD:410628 10/24 (42%)
htr1aaNP_001116793.1 7tm_GPCRs 29..387 CDD:475119 129/822 (16%)
TM helix 1 31..55 CDD:410628 8/23 (35%)
TM helix 2 64..86 CDD:410628 14/21 (67%)
TM helix 3 102..124 CDD:410628 13/21 (62%)
TM helix 4 147..163 CDD:410628 4/15 (27%)
TM helix 5 185..208 CDD:410628 8/22 (36%)
TM helix 6 321..343 CDD:410628 9/21 (43%)
TM helix 7 355..380 CDD:410628 10/24 (42%)

Return to query results.
Submit another query.