Protein Alignment 5-HT2B and htr2cl1

DIOPT Version :10

• Sequence 1: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Sequence 2: XP_073762008.1
• Gene: htr2cl1 / 100000981
• ZFINID: ZDB-GENE-081104-48
• Length: 531
• Species: Danio rerio
• Alignment Length: 924
• Identity: 192/924 - (20%)
• Similarity: 275/924 - (29%)
• Gaps: 497/924 - (53%)

  Fly    42 TSRHNQLHVARWNA-TGNATIS--ATFEDVPFDAN--------------------NYWALLALVL 83
            :|..:.|.:..|.. .||.|:|  .:|....:..|                    |:.|||.||:
Zfish    14 SSTTSSLDLVGWMIWPGNTTVSLNQSFFGTDYSFNLSSSSSSSPHGVKREEMKEKNWPALLILVI 78

  Fly    84 VLGTAAGNILVCLAIAWERRLQNVTNYFLMSLAITDLMVAVLVMPLGILTLVKGY-FPLGSEHCL 147
            ::.|..|||||.||::.|::|||.||:||.|||:.|::|.:||||:.::.::..| :||.|..|.
Zfish    79 IILTIGGNILVILAVSLEKKLQNATNFFLRSLAVADMLVGILVMPISLINILYDYAWPLPSALCP 143

  Fly   148 TWICLDVLFCTASIMHLCTISVDRYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSI---------- 202
            .||.|||||.||||||||.||:|||:::|.|:...|..:|.:..|||..||.:||
Zfish   144 IWIYLDVLFSTASIMHLCAISLDRYVAIRNPIEHSRFNSRTKAMLKIAAVWTISIGQRNTDLMIL 208

  Fly   203 ---AMSLPLSLMYSKNHASVLVNGTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQ 264
               .:|:|:.::...|...||.||.|.:.:.::.||||.|.|:|||.:|::||||||:.|.||
Zfish   209 SKTGISMPIPVIGLSNREKVLKNGICALNEELFILVGSFVAFFIPLVIMVVTYCLTVQALQRQ-- 271

  Fly   265 NLGGGQQTAAATPGWASGWLGQAPALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNH 329
                           |:.:|.:                  |.|||
Zfish   272 ---------------ATVFLYE------------------GKASS-------------------- 283

  Fly   330 ELWLPDSSIKEPTPTTMTALHQFGAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSP 394
                 ...::.|.|.:.                                        ||..|.:|
Zfish   284 -----QQPLQPPAPPSS----------------------------------------QLVPPLAP 303

  Fly   395 QRYAATHQQSHHHNHQQHPAGVYHQQASPKGRHGTTVLGLSTTTLGIERESTRNSLASSRMGGEQ 459
            .|                                                  |:||...|:  ..
Zfish   304 SR--------------------------------------------------RSSLNCLRI--SN 316

  Fly   460 SDGTLSQLSQRLRAYKKRRRASSAVPGREKRAGHEDADEDVETPTSTLRRHKRHNSLPKNALYPR 524
            |||....|
Zfish   317 SDGNTLGL--------------------------------------------------------- 324

  Fly   525 HTTVQESLDDDDDEEEESAQQKDQQTKSKICHSDTELDPPQKAKQCHIAGQNHQSDYLQLPSVCT 589
              ||                                  ||.
Zfish   325 --TV----------------------------------PPD------------------------ 329

  Fly   590 CPYFGDRPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEMELLMCSSGNKKSLTSSVSAGITGG 654
                            .:.||.|           |.:||:|                      ..
Zfish   330 ----------------TISIIPS-----------SEAPSQM----------------------NS 345

  Fly   655 PAGAAPATVGSTLSPHSAHNQGSSLTVQSDGSGYLAAPGTPCPGRRKLSISKTASVVTWDSSRHR 719
            |||..||                                                      ..|.
Zfish   346 PAGRDPA------------------------------------------------------GAHG 356

  Fly   720 RRGSSFGGVRTSLLLTPTKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSSPCMLQ 784
            |||                                                           |:|
Zfish   357 RRG-----------------------------------------------------------MMQ 362

  Fly   785 RQQTVRSHHSRNSSVISRNSSRHGRIIRLEQKATKVLGVVFFTFVILWSPFFVLNLLPTVC-AEC 848
                                     .|:.|::|:||||||||.|:.:|.|||:.|:|..:| ..|
Zfish   363 -------------------------AIKNERRASKVLGVVFFLFLFMWCPFFITNVLYVLCHRTC 402

  Fly   849 EERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQAFKKVLLCRYSSTSAWRPSRXQTPVKPGK 913
            :|.:...:.:|..|:||.||.|||:.||:|||.:|:||...:.|:|..... :|.....|.....
Zfish   403 KETLLTELLNVFVWVGYISSGVNPLVYTLFNKTYRRAFSNYMHCQYRHVGL-KPITINVPCPSHA 466

  Fly   914 LKTNTHKC--ASVD 925
            :.|....|  .|:|
Zfish   467 VVTPILMCDKVSID 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
5-HT2B	NP_001262373.1	7tmA_5-HT2_insect-like	74..>267	CDD:320433	94/206 (46%)
		TM helix 1	75..101	CDD:320433	13/25 (52%)
		TM helix 2	108..134	CDD:320433	13/25 (52%)
		TM helix 3	146..176	CDD:320433	21/29 (72%)
		TM helix 4	188..211	CDD:320433	9/35 (26%)
		TM helix 5	229..258	CDD:320433	16/28 (57%)
		7tm_GPCRs	<799..893	CDD:475119	38/94 (40%)
		TM helix 6	818..840	CDD:410628	13/21 (62%)
		TM helix 7	854..879	CDD:410628	11/24 (46%)
htr2cl1	XP_073762008.1	None