Protein Alignment Cenp-C and set-2

DIOPT Version :10

• Sequence 1: NP_731254.2
• Gene: Cenp-C / 41014
• FlyBaseID: FBgn0266916
• Length: 1411
• Species: Drosophila melanogaster
• Sequence 2: NP_498039.1
• Gene: set-2 / 175662
• WormBaseID: WBGene00004782
• Length: 1510
• Species: Caenorhabditis elegans
• Alignment Length: 1540
• Identity: 303/1540 - (19%)
• Similarity: 521/1540 - (33%)
• Gaps: 440/1540 - (28%)

  Fly   107 PPRRSPTLSPNNRRSMRRSGNVPGSDKLRRHAIRRRSRSCGRQLLPEFEETVNLTRSISSPVNFL 171
            |||:|     :::|....|.|  ...|:..|       .|.......||...:..|....|.:
 Worm    10 PPRKS-----HSKRDKPSSSN--SGPKIENH-------KCKWAWQKVFETGKSFLRRDGFPQD-- 58

  Fly   172 PEISSTPCTEKQKEEVAKNT-TRVETDKPAEKPMELSQEPEPENPLQTK---------------- 219
                   |..|:..|..|.| .|..::...|.|.:..:..:..:..||.
 Worm    59 -------CKSKEDFERIKRTGVRKTSENMLEDPRKNFESLQQSSVYQTNSFRNPRYLCRAHLRVD 116

  Fly   220 ---VTSPARNPILAAEIEQICKERQSSFHKNVLQLDYS---GRAPYS----RPPTPSSPSVAGLR 274
               .|.|.:..:....::..|.|        ||..|::   |:...:    .|.|.....:|.::
 Worm   117 SYYCTIPPKREVSLFNMDDNCTE--------VLLRDFAKDCGKVEKAYVCIHPETKRHMKMAYVK 173

  Fly   275 --------RTYTMEKGPAPGQLLLSPSHRYDTPSKMPVVKAKRFNQEL----------MVPDTPE 321
                    ..|:|..    .|.||:..   .||...|.:..  .|:|.          ::||  :
 Worm   174 FATVKEAHNFYSMYH----AQNLLATK---CTPRIDPFLSI--LNEEYEVATNGQVLPILPD--D 227

  Fly   322 RQSHDPAWQSEPQPEFVVPETQPQDLGELVQTLSRSAISPIVVINTSN-------SNRSVRRDAV 379
            ..|.||:...:.:..|:..:.:..:|...........:...|:::||:       .:..|...::
 Worm   228 LASIDPSVLRDLRANFLRDQNEKYELAMRNTYEDEGGMLSGVIMDTSDHYERDYTMDHDVGPSSM 292

  Fly   380 AMKSVPTSPVTALSSPPIAPSPRRSAA-ASPQKSIAQLPRVEENMDAIMTDDESDEHPSTVPLNL 443
            .|..:|..|:...|.||..|.|..|.: .:|..|: |||....    |.....:...|...|...
 Worm   293 KMSPIPPPPIKEESPPPPPPPPVASVSNLAPVPSV-QLPYYNN----IQPSSSTMHMPEFRPTEP 352

  Fly   444 APSGG------NTTRQRRLRSSNRARATIESQESSMRLLNLHKSVNAKKSKPRKT-AIPLNKAPS 501
            .||..      :|:|....|..||:|:..:..:.|.|            |..|:| ..|.::..|
 Worm   353 PPSYSREDPYRSTSRSSLSRHRNRSRSPSDGMDRSGR------------SSSRRTHRRPESRNGS 405

  Fly   502 APINGEQFARELTRM-----------SNYEILDLRKRNSL----NEIYPLNGHRNHRSEKLILEE 551
            ...||:....|..:|           ..||.:.:::|.::    |::..::......|..:....
 Worm   406 KNANGDVVKYETYKMEKRKIKYEGGNKKYEQVHIKERTAVIRGKNQLENVSSESASGSSSVDTYP 470

  Fly   552 EIQRELLRRNLMDEAEGLPKQ-------QSSDDSNEDYIPVPPKTQSLRTKSNDRSQGRGRPR-- 607
            :...|..::....::....|:       .|:|:|:||          .|.:.:.|||.|...|
 Worm   471 DFSDEERKKKKRPKSPNRSKKDSRAFGWDSTDESDED----------TRRRRSGRSQNRSSERKF 525

  Fly   608 ------STRRDLPMT-TELVNYLGLSQTLETRRKSSKDGKRCLYTKGSSDHEDNDSLSPVKLPRL 665
                  ||||:|..| |..|..|   ::.||.......|...::.:....|     :.|..:|..
 Worm   526 QTTSSSSTRRELSSTHTNSVPNL---KSHETPPPPPPKGHPSVHLQTPYQH-----VQPQMIPAT 582

  Fly   666 SKSI--QIVPPPPVSLRYSQSLQNLP--CSGKFDFDNVVMAAPPDFHDSVNSDAIEIAPPPPEYV 726
            ..::  |.:.|||::       .:||  |    ||........|.|....|      ||.|..|.
 Worm   583 YYNLPPQHMAPPPIT-------TSLPPFC----DFSQPPPGFTPTFKPITN------APLPTPYQ 630

  Fly   727 VN-------TRGRSTSGRKSNKNDLVLPPPGYEGGQEE-EHDERPSQPRCTAK--ELQQSTQNGR 781
            .:       .:..:.|......:.:..||||....||: ...|.|.:|..:.:  .:...||...
 Worm   631 ASNIPQPGLVQIAALSAAPEPFSSIPGPPPGPAPIQEDVGRAESPEKPSLSERFSGIFGPTQREE 695

  Fly   782 RAMENELVPPPIEYVEEENRNNEQSRRSTKNGNL---VDRNTHNAVEYCEPPEPPEYDDSDH--- 840
            .|........|:::.|     :...|.|.::.::   .|..|.:.||..|..|..:..|.:.
 Worm   696 PAQVEVEYDYPLKHSE-----SHDDRHSLEDMDVEVSSDGETVSNVEKIECMEEKKRQDLERIAI 755

  Fly   841 GQASILRRSGKKLQHS-KQSVQKSNKEQIIAPSYENNEDYDSDE----EPIYNEEYGKEESQNKN 900
            .:..|:::..|::... .:.|.:..::||:...:.     ..||    :.|.:||..|:|.:.|
 Worm   756 ARTPIVKKCKKRMMDELSRKVAEDIRQQIMRQCFA-----ALDEKLHLKAIADEEKRKKEREEK- 814

  Fly   901 VTRRKSDK-------DEMASHTLECIEG-------------PDPNWNSSCNKQNRNHQNASKSKE 945
             .|::::|       |.|.|.||...:.             |.|   .|..|...:|.:|..|..
 Worm   815 -ARQEAEKPSNHLIADMMPSQTLYNNQSFASSSRGFYRKQKPIP---KSHPKHQEHHHHAKASVS 875

  Fly   946 NDKLANRSSKSQKLSNPRQNAVGTEKSVALSNRGEECTEKSSDVMESLRVNTPTPPIDQNSDDVP 1010
            ....::.:|::..::...|..|.|..|             ||....|.||:..    :.:||..|
 Worm   876 TPVHSSSTSRNSSVAPTPQRTVSTSSS-------------SSSAATSARVSED----ESDSDSTP 923

  Fly  1011 SRNPSPSRTLLSDDVPSTSRAALEFLQRSQNMSKSRPPDESSADVVFKKPLAPAPRAKSKKGKSE 1075
            ........::||:|   ..|....|...|...|..|..|.||:    .:..:.:..:..|:.::.
 Worm   924 GEVQRRKTSVLSND---KRRRRASFSSTSIQSSPERQRDVSSS----SRTSSSSSTSSMKQEETA 981

  Fly  1076 VDKLKLAKMPVEAEELNTTGIRRSKRGQVPLQMSWCHTMDPSKFNFMSGFIEPRSKNSKTK--KG 1138
            .:|.:..|:.:.::|.:|||  .:....|..:.|   :::|.: ....|  ||..|.|:|.  ..
 Worm   982 DEKSRKRKLIMSSDESSTTG--STATSVVSSRQS---SLEPQQ-EKTDG--EPPKKKSQTDFISE 1038

  Fly  1139 NLSKAKKASATKPKPT-------------------------VEKNLP------------------ 1160
            .:||.:......|:|.                         :|.|||
 Worm  1039 RVSKIEGEERPLPEPVETSGPIIGDSSYLPYKIVHWEKAGIIEMNLPANSIRAHEYHPFTTEHCY 1103

  Fly  1161 ----DNRGP---LCSSTPRISEKLPGAIPHSESLGLSTLTWEETEVQAE-----------AEKVP 1207
                |.|.|   :...:|..||      |.||.|.::...|...:..||           |.|..
 Worm  1104 FGIDDPRQPKIQIFDHSPCKSE------PGSEPLKITPAPWGPIDNVAETGPLIYMDVVTAPKTV 1162

  Fly  1208 KKRGRPKKAVGGVQTDTEAEPEPEPEPMISSVAPLTSDQEEPDVPDEQAPYTEAALGPVVFSTPL 1272
            :|:.:|:|.|      .|.:|....||                      |.|:....|..|....
 Worm  1163 QKKQKPRKQV------FEKDPYEYYEP----------------------PPTKRPAPPPRFKKTF 1199

  Fly  1273 RDEQEEASTKLM-----------QW-LRGVGDAPPSASMSDENASVSSANELIFCQV-------- 1317
            :...||...|::           || ||        |::::..:.|.||:||.:.::
 Worm  1200 KPRSEEEKKKIIGDCEDLPDLEDQWYLR--------AALNEMQSEVKSADELPWKKMLTFKEMLR 1256

  Fly  1318 --------------DGIDYAFYNTKE-----KAMLGYMRFKPYQKRSMKQAK---------VHPL 1354
                          .|:..|||..:|     ....|..|.:||:|.:|||.:         .||.
 Worm  1257 SEDPLLRLNPIRSKKGLPDAFYEDEELDGVIPVAAGCSRARPYEKMTMKQKRSLVRRPDNESHPT 1321

  Fly  1355 KLLVQFGEFNVETLAVGEEKEVHSVLRVGDMIEIDRGTRYSIQNA 1399
            .:..:..|..:.          |..|...||..:.|....|:.:|
 Worm  1322 AIFSERDETAIR----------HQHLASKDMRLLQRRLLTSLGDA 1356

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cenp-C	NP_731254.2	None
set-2	NP_498039.1	RRM_SF	124..213	CDD:473069	19/105 (18%)
		SET_SETD1	1359..1506	CDD:380946