DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pch2 and TRIP13

DIOPT Version :9

Sequence 1:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_004228.1	Gene:	TRIP13 / 9319	HGNCID:	12307	Length:	432	Species:	Homo sapiens

Alignment Length:	437	Identity:	186/437 - (42%)
Similarity:	268/437 - (61%)	Gaps:	50/437 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSNSDTVHVEVCLRGNDLRSNAIRNNVETALKAYFQTARKLPRNVSFLPDLTAEQ------TEHV 62
            ::.|.||||||..||:   |.|.:.::..:::      :.|.|:.....|.|..:      |.:|
Human    15 VAESPTVHVEVHQRGS---STAKKEDINLSVR------KLLNRHNIVFGDYTWTEFDEPFLTRNV 70

  Fly    63 HSV------LLERDNGGVQPLKVAETKFRFHFYATRPEEGQLGLFSGEEGSDGIDSIVAASHALL 121
            .||      |..:|:   ||:.::......|.:... |:|.    |.|...:..::|:||:|.:|
Human    71 QSVSIIDTELKVKDS---QPIDLSACTVALHIFQLN-EDGP----SSENLEEETENIIAANHWVL 127

  Fly   122 PAAQFVGLWENLIYETGLKEKLLKFALSALMFSEHRVDTNVIACNRLILLHGPPGTGKTSLCKAL 186
            |||:|.|||::|:|:..:|..||.:.::.|:||:..|::|:|..||::|||||||||||||||||
Human   128 PAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGPPGTGKTSLCKAL 192

  Fly   187 AQKLSIRTQGSYAYTHLVEINSHSLFSKWFSESGKLVAQLFNKIAELVSDPNNLVCVLIDEVESL 251
            ||||:||....|.|..|:|||||||||||||||||||.::|.||.:|:.|.:.||.|||||||||
Human   193 AQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLIDDKDALVFVLIDEVESL 257

  Fly   252 AYARSA-MSSNEPRDAMRVVNAVLTQLDSLKTCPNVLILATSNLAQSIDLAFVDRADIRLFIGYP 315
            ..||:| .:..||.||:|||||||||:|.:|...||:||.|||:.:.||:||||||||:.:||.|
Human   258 TAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSNITEKIDVAFVDRADIKQYIGPP 322

  Fly   316 GISAIREIYKGMLAELMSAGVL--QREVLESEDAE------------EGLLTQLAERSVGLSGRT 366
            ..:||.:||...|.|||...::  ::::|...:.|            ..||..::.:|.|||||.
Human   323 SAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIGFIENNVSKLSLLLNDISRKSEGLSGRV 387

  Fly   367 LRKLPLLAHAQYTSSTLFELDQKISLSDFLDAMLEALEQHLGEQRLL 413
            |||||.||||.|..:      ..:::..||.|:..|:::...|::.|
Human   388 LRKLPFLAHALYVQA------PTVTIEGFLQALSLAVDKQFEERKKL 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_001287235.1	AAA	166..315	CDD:214640	100/149 (67%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	97/145 (67%)
TRIP13	NP_004228.1	SpoVK	<136..360	CDD:223540	123/223 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144817
Domainoid	1	1.000	193	1.000	Domainoid score	I3196
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3125
Inparanoid	1	1.050	303	1.000	Inparanoid score	I2674
Isobase	1	0.950	-	0	Normalized mean entropy	S1847
OMA	1	1.010	-	-		QHG57461
OrthoDB	1	1.010	-	-		D1036414at2759
OrthoFinder	1	1.000	-	-		FOG0005740
OrthoInspector	1	1.000	-	-		oto88350
orthoMCL	1	0.900	-	-		OOG6_103946
Panther	1	1.100	-	-	LDO	PTHR45991
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2222
SonicParanoid	1	1.000	-	-		X4134
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750