DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pch2 and SPATA5L1

DIOPT Version :9

Sequence 1:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_076968.2	Gene:	SPATA5L1 / 79029	HGNCID:	28762	Length:	753	Species:	Homo sapiens

Alignment Length:	359	Identity:	93/359 - (25%)
Similarity:	146/359 - (40%)	Gaps:	83/359 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 EEGQLGLFSGEEGSDG--IDSI--VAASHALLPAA--QFVGL-------WENLIYETGLKEKLLK 145
            |.....|...|:..|.  ||.|  :.|...:.|::  ..:||       ||.:   .||::..||
Human   414 EAAMHALLHSEKNQDNPVIDEIDFLEAFKNIQPSSFRSVIGLMDIKPVDWEEI---GGLEDVKLK 475

  Fly   146 FALS---ALMFSEHRVDTNVIACNRLILLHGPPGTGKTSLCKALAQKLSIRTQGSYAYTHLVEIN 207
            ...|   .|.|....|... :...:.:||:||||..||:|.:|||         :..:...|.::
Human   476 LKQSIEWPLKFPWEFVRMG-LTQPKGVLLYGPPGCAKTTLVRALA---------TSCHCSFVSVS 530

  Fly   208 SHSLFSKWFSESGKLVAQLFNKIAELVSDPNNLVCVLIDEVESLAYARSAMSSNEPRDAM-RVVN 271
            ...|||.:..:|.|:::|:|.:..  .|.|   ..:.:||::|:..||||  |....|.. ||::
Human   531 GADLFSPFVGDSEKVLSQIFRQAR--ASTP---AILFLDEIDSILGARSA--SKTGCDVQERVLS 588

  Fly   272 AVLTQLD--SLKTCP-----------------NVLILATSNLAQSIDLAFV--DRADIRLFIGYP 315
            .:|.:||  .|||..                 :|:|:|.:|....:|.|.:  .|.|..::|..|
Human   589 VLLNELDGVGLKTIERRGSKSSQQEFQEVFNRSVMIIAATNRPDVLDTALLRPGRLDKIIYIPPP 653

  Fly   316 GISAIREIYKGMLAELMSAGVLQREVLESEDAEEGLLTQLAERSVGLSGRTLRKLPLLAHAQYTS 380
            .       :||.|:.|.   |..:.:....|..   |..||..:...||..||.|       .|.
Human   654 D-------HKGRLSILK---VCTKTMPIGPDVS---LENLAAETCFFSGADLRNL-------CTE 698

  Fly   381 STLFELDQKISLSDFLDAMLEALEQHLGEQRLLK 414
            :.|..|.:     :.|||.....|..|...:.:|
Human   699 AALLALQE-----NGLDATTVKQEHFLKSLKTVK 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_001287235.1	AAA	166..315	CDD:214640	48/170 (28%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	48/166 (29%)
SPATA5L1	NP_076968.2	CDC48	22..746	CDD:273521	93/359 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..203
		AAA	237..367	CDD:278434
		AAA	501..651	CDD:278434	47/165 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900