DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pch2 and Pex1

DIOPT Version :9

Sequence 1:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001280735.1	Gene:	Pex1 / 71382	MGIID:	1918632	Length:	1284	Species:	Mus musculus

Alignment Length:	417	Identity:	99/417 - (23%)
Similarity:	156/417 - (37%)	Gaps:	93/417 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 KLPRNVSFLPDL----TAEQTE-------------HVHSVLLERDNGGVQPLKVAETKFRFHFYA 90
            ||..::|..|||    .|:.||             .:||.|..:.:...:.|.:..:.|:.....
Mouse   757 KLGCDISNFPDLDLQCIAKDTEAFVARDFTVLVDRAIHSSLSRQHSSSREDLTLTTSDFQKALRG 821

  Fly    91 TRPEE-GQLGLFSGEE-GSDGIDSIVAASHALLPAAQFVGLWENLIYETGLKEKLLKFALSALMF 153
            ..|.. ..:.|....: |.|.|..:......|:...|....:..|.....::::
Mouse   822 FLPASLRNVNLHKPRDLGWDKIGGLHEVRQILMDTIQLPAKYPELFANLPIRQR----------- 875

  Fly   154 SEHRVDTNVIACNRLILLHGPPGTGKTSLCKALAQKLSIRTQGSYAYTHLVEINSHSLFSKWFSE 218
                  |.       |||:||||||||.|...:|::..:         :.:.|....|.||:...
Mouse   876 ------TG-------ILLYGPPGTGKTLLAGVVARESGM---------NFISIKGPELLSKYIGA 918

  Fly   219 SGKLVAQLFNKIAELVSDPNNLVCVL-IDEVESLAYARSAMSSNEPRDAMRVVNAVLTQLDSLKT 282
            |.:.|..:|  |....:.|    |:| .||.||:| .|....:....|  ||||.:|||||.::.
Mouse   919 SEQAVRDVF--IRAQAAKP----CILFFDEFESIA-PRRGHDNTGVTD--RVVNQLLTQLDGVEG 974

  Fly   283 CPNVLILATSNLAQSIDLAFV--DRADIRLFIGYPGISAIREIYKGMLAELMSAGVLQREVLESE 345
            ...|.:||.::....||.|.:  .|.|..::...|          ..::.|....||.:.:..::
Mouse   975 LQGVYVLAATSRPDLIDPALLRPGRLDKCVYCPPP----------DQVSRLEILTVLSKSLALAD 1029

  Fly   346 DAEEGLLTQLAERSVGLSGRTLRKLPLLAHAQYTSSTLF---------ELDQKISLSD--FLDAM 399
            |.:   |..:|..:...:|..|:.|...|..:.....|.         ..|..:|||.  ||:..
Mouse  1030 DVD---LQHVASVTDSFTGADLKALLYNAQLEALQGRLLPSGLPDGGSSSDSDLSLSSMVFLNHS 1091

  Fly   400 L----EALEQHLG-EQRLLKLESMEQL 421
            .    .|.:...| ||.||.||..|.|
Mouse  1092 SGSDDSAGDGECGLEQSLLSLEMSEIL 1118

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_001287235.1	AAA	166..315	CDD:214640	48/151 (32%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	48/147 (33%)
Pex1	NP_001280735.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	339..373
		AAA	592..742	CDD:214640
		AAA	596..725	CDD:278434
		AAA	878..1010	CDD:214640	49/159 (31%)
		AAA	878..1007	CDD:278434	48/146 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1261..1284
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900