DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment pch2 and Nvl

DIOPT Version :9

Sequence 1:NP_001287235.1 Gene:pch2 / 41013 FlyBaseID:FBgn0051453 Length:421 Species:Drosophila melanogaster
Sequence 2:NP_080447.1 Gene:Nvl / 67459 MGIID:1914709 Length:855 Species:Mus musculus


Alignment Length:475 Identity:116/475 - (24%)
Similarity:188/475 - (39%) Gaps:125/475 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 EVCLRGNDLRSNAIRNNVETALKAYFQT-ARK--LPRNVSFL-----------PDLTAEQTE--- 60
            ||||...|          |.|.:...|| .||  ||...:|.           .||.|...|   
Mouse   428 EVCLGIPD----------EAARERILQTLCRKLRLPETFNFCHLAHLTPGFVGADLMALCREAAM 482

  Fly    61 -HVHSVLLERDNGGVQPLKVAETKFRFHFYATRPEEGQ--------------------LGLFS-- 102
             .|:.||:::.   .|..|..|.:       ..|.||.                    |||..  
Mouse   483 CAVNRVLMKQQ---AQQKKKPEIE-------GLPSEGDQEERLGAEPTSETQDELQRLLGLLRDQ 537

  Fly   103 ---GEEGSDGI-----DSIVAASHALLPAAQFVGL-------WENLIYETGLKEKLLKFALSALM 152
               .||...|:     |.|||.:. :.|:|:..|.       |.::.....::::|: .|:.|.:
Mouse   538 DPLSEEQMQGLCIELNDFIVALAE-VQPSAKREGFVTVPNVTWADIGALEDIRDELI-MAILAPV 600

  Fly   153 FSEHRVDTNVIACNRLILLHGPPGTGKTSLCKALAQKLSIRTQGSYAYTHLVEINSHSLFSKWFS 217
            .:..:..|..:.....|||.||||.|||.|.||:|.:..:         :.:.:....|.:.:..
Mouse   601 RNPDQFRTLGLGTPAGILLAGPPGCGKTLLAKAVANESGL---------NFISVKGPELLNMYVG 656

  Fly   218 ESGKLVAQLFNKIAELVSDPNNLVCVL-IDEVESLAYARSAMSSNEPRDAMRVVNAVLTQLDSLK 281
            ||.:.|.|:|.:.      .|:..||: .|||::|...|   |..|...::||||.:||::|.|:
Mouse   657 ESERAVRQVFQRA------KNSAPCVIFFDEVDALCPRR---SDRETGASVRVVNQLLTEMDGLE 712

  Fly   282 TCPNVLILATSNLAQSIDLAFV--DRADIRLFIGYP----GISAIREIYKG----MLAELMSAGV 336
            |...|.|||.:|....||.|.:  .|.|..||:|.|    .::.::.|.|.    .|.|.::...
Mouse   713 TRQQVFILAATNRPDIIDPAILRPGRLDKTLFVGLPPPADRVAILKTITKNGTKPPLDEDVNLET 777

  Fly   337 LQREV------------LESEDAEEGLLTQLAERSVGLSGRTLRKLPLLAHAQYTSSTLFELDQK 389
            :..::            |..|.:...|..::..:..|:....|:    ::|..: .....::...
Mouse   778 IANDLRCNCYTGADLTALVREASLCALRQEITAQKNGVGAGELK----VSHKHF-EDAFKKVKPS 837

  Fly   390 ISLSDFLDAMLEALEQHLGE 409
            ||:.|  ..|.|||::.|.:
Mouse   838 ISIKD--QVMYEALQRSLSQ 855

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
pch2NP_001287235.1 AAA 166..315 CDD:214640 52/151 (34%)
AAA 169..314 CDD:278434 51/147 (35%)
NvlNP_080447.1 Interaction with RPL5. /evidence=ECO:0000250|UniProtKB:O15381 1..219
Nucleolin_bd 2..72 CDD:293330
Nucleolar localization signal. /evidence=ECO:0000269|PubMed:21474449 49..52
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 83..234
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381 85..88
Nuclear localization signal. /evidence=ECO:0000250|UniProtKB:O15381 217..231
Interaction with WDR74. /evidence=ECO:0000250|UniProtKB:O15381 266..473 14/54 (26%)
SpoVK 283..842 CDD:223540 110/458 (24%)
AAA 300..432 CDD:278434 3/3 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 496..523 5/33 (15%)
AAA 617..747 CDD:278434 51/147 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0464
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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