DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pch2 and Fign

DIOPT Version :9

Sequence 1:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_068362.1	Gene:	Fign / 60344	MGIID:	1890647	Length:	759	Species:	Mus musculus

Alignment Length:	446	Identity:	99/446 - (22%)
Similarity:	165/446 - (36%)	Gaps:	110/446 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 NDLRSNAIRNNVETALKAYFQTARKLPRNVSFLPDLTAEQTEHVHSVLLERDNGGVQPLKVAETK 83
            |..|.|....|.||:..|:..|.:.:|          :||.....|    :.:..:.|...:..|
Mouse   358 NSNRGNGFDRNAETSSLAFKPTKQLMP----------SEQQRKFSS----QSSRALTPPSYSTAK 408

  Fly    84 FRFHFYATRPEEGQLGLFS----GEEGSD------------GIDSIVAASHAL-----LPAAQFV 127
               :...:|..| ..|.::    .|.|.|            |:.:..:::|::     ......:
Mouse   409 ---NSLGSRSSE-SFGKYTSPVMSEHGDDHRQLLAHPIQGPGLRAATSSNHSVDEQLKNTDTHLI 469

  Fly   128 GLWENLIYETG-----------------LKEKLLKFALSALMFSEHRVDTNVIACNRLILLHGPP 175
            .|..|.|...|                 :||::|...|.:..||      .:.|..|.|||.||.
Mouse   470 DLVTNEIITQGPPVDWSDIAGLDLVKAVIKEEVLWPVLRSDAFS------GLTALPRSILLFGPR 528

  Fly   176 GTGKTSLCKALAQKLSIRTQGSYAYTHLVEINSHSLFSKWFSESGKLVAQLFNKIAELVSDPNNL 240
            |||||.|.:.:|.:|.         ....:|....|.:||..|:.|::...|     ||:.....
Mouse   529 GTGKTLLGRCIASQLG---------ATFFKIAGSGLVAKWIGEAEKIIHASF-----LVARCRQP 579

  Fly   241 VCVLIDEVESLAYARSAMSSNEPRDAMRVVNAVLTQLDSLKTCPN---VLILATS---NLAQSID 299
            ..:.:.:::.|.   |:..|.|.....|:....|.|||::.|...   |:|.|||   .:.:|:.
Mouse   580 SVIFVSDIDMLL---SSQVSEEHSPVSRMRTEFLMQLDTVLTSAEDQIVVICATSKPEEIDESLR 641

  Fly   300 LAFVDRADIRLFIGYPGISAIREIYKGMLAELMSAGVLQREVLESEDAEEGLLTQLAERSVGLSG 364
            ..|:.    ||.|..|..:|..:|...:|.:       ....|  .|.|..||.|   |:.|.||
Mouse   642 RYFMK----RLLIPLPDSTARHQIIVQLLTQ-------HNYCL--NDKEFALLVQ---RTEGFSG 690

  Fly   365 RTLRKL-------PLLAHAQYTSSTLFELD-QKISLSDFLDAMLEALEQHLGEQRL 412
            ..:..|       ||.|......|.:.... :.::..||.:|..: ::..:.::.|
Mouse   691 LDVAHLCQEAAVGPLHAMPATDLSAIMPSQLRPVTYQDFENAFCK-IQPSISQKEL 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_001287235.1	AAA	166..315	CDD:214640	43/154 (28%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	42/150 (28%)
Fign	NP_068362.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	89..111
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	200..237
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	258..293
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	337..429		17/88 (19%)
		26Sp45	389..736	CDD:130309	87/394 (22%)
		AAA	522..652	CDD:278434	42/150 (28%)
		Vps4_C	<723..756	CDD:286426	4/24 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900