Protein Alignment pch2 and PEX6

DIOPT Version :9

• Sequence 1: NP_001287235.1
• Gene: pch2 / 41013
• FlyBaseID: FBgn0051453
• Length: 421
• Species: Drosophila melanogaster
• Sequence 2: NP_000278.3
• Gene: PEX6 / 5190
• HGNCID: 8859
• Length: 980
• Species: Homo sapiens
• Alignment Length: 487
• Identity: 105/487 - (21%)
• Similarity: 187/487 - (38%)
• Gaps: 136/487 - (27%)

  Fly     4 LSNSDTVH-------VEVCLRGNDLRSNAIRNNVETALKAYFQTARKLP-----RNVSFLPDLTA 56
            |.|.|.::       |....|..||.:     :|:||    |....::|     :.:|.|..|||
Human   555 LLNEDPLNSCPPLMVVATTSRAQDLPA-----DVQTA----FPHELEVPALSEGQRLSILRALTA 610

  Fly    57 EQT--EHVHSVLLERDNGG----------VQPLKVAETKFRFHFYA---TRPEEGQL---GL-FS 102
            ...  :.|:...|.|...|          ....:.|.|:.:....|   |..:||:|   |. ..
Human   611 HLPLGQEVNLAQLARRCAGFVVGDLYALLTHSSRAACTRIKNSGLAGGLTEEDEGELCAAGFPLL 675

  Fly   103 GEEGSDGIDSIVAASHALLPAAQFVGL-WENLIYETGLKEKLLKFALSALMFSEHRVDTNVIACN 166
            .|:....::.:..|....:.|.:...: |    ::.|..:::.|..|..:.......:...:...
Human   676 AEDFGQALEQLQTAHSQAVGAPKIPSVSW----HDVGGLQEVKKEILETIQLPLEHPELLSLGLR 736

  Fly   167 RL-ILLHGPPGTGKTSLCKALAQKLSIRTQGSYAYTHLVEINSHSLFSKWFSESGKLVAQLFNKI 230
            |. :|||||||||||.|.||:|.:.|:.         .:.:....|.:.:..:|.:.|.::|.:.
Human   737 RSGLLLHGPPGTGKTLLAKAVATECSLT---------FLSVKGPELINMYVGQSEENVREVFARA 792

  Fly   231 AELVSDPNNLVCVL-IDEVESLAYARSAMSSNEPRDAM-RVVNAVLTQLDSLKTCPNVLILATSN 293
            .....      |:: .||::|||.:|.  .|.:....| |||:.:|.:||.|.:..:|.::..:|
Human   793 RAAAP------CIIFFDELDSLAPSRG--RSGDSGGVMDRVVSQLLAELDGLHSTQDVFVIGATN 849

  Fly   294 LAQSIDLAFV--DRADIRLFIG---------------------YPGISAIR------------EI 323
            ....:|.|.:  .|.|..:|:|                     .|.:|.:.            ::
Human   850 RPDLLDPALLRPGRFDKLVFVGANEDRASQLRVLSAITRKFKLEPSVSLVNVLDCCPPQLTGADL 914

  Fly   324 YKGMLAELMSAGVLQREVLESEDAEEGLLTQLAERSVGLSGRTLRKLPLLAHAQYTSSTLFELDQ 388
            | .:.::.|:| .|:|.|   .|.||||                         :..||.|.
Human   915 Y-SLCSDAMTA-ALKRRV---HDLEEGL-------------------------EPGSSALM---- 945

  Fly   389 KISLSDFLDAMLEALEQHLGEQRLLKLESMEQ 420
             :::.|.|.|... |:..:.||.||:.:.:::
Human   946 -LTMEDLLQAAAR-LQPSVSEQELLRYKRIQR 975

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_001287235.1	AAA	166..315	CDD:214640	45/174 (26%)
		AAA	169..314	CDD:278434	44/169 (26%)
PEX6	NP_000278.3	SpoVK	463..967	CDD:223540	103/477 (22%)
		AAA	466..594	CDD:278434	11/47 (23%)
		AAA	743..871	CDD:278434	41/144 (28%)
		Vps4_C	918..977	CDD:286426	21/93 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900