DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pch2 and Pex1

DIOPT Version :9

Sequence 1:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001102690.1	Gene:	Pex1 / 500006	RGDID:	1559939	Length:	1283	Species:	Rattus norvegicus

Alignment Length:	463	Identity:	106/463 - (22%)
Similarity:	171/463 - (36%)	Gaps:	112/463 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 LSNSDTVHVEVCLR-----GNDLRSNAIRNNVETALKAYFQTARKLPRNVSFLPDL----TAEQT 59
            |.::..||...|::     ..:.|...:.:.|:          .||..::|..|||    .|::|
  Rat   722 LVSAQGVHTFQCIQHIQPPDQEQRCEILHSVVK----------NKLGCDISKSPDLDLKCIAKET 776

  Fly    60 E-------------HVHSVLLERDNGGVQPLKVAETKFRFHFYATRPEE-GQLGLFSGEE-GSDG 109
            |             .:||.|..:.|...:.|.:....|:.......|.. ..:.|....: |.|.
  Rat   777 EAFVARDFTVLVDRAIHSSLSRQQNPTREGLTLTTADFQKALRGFLPASLRNVNLHKPRDLGWDK 841

  Fly   110 IDSIVAASHALLPAAQFVGLWENLIYETGLKEKLLKFALSALMFSEHRVDTNVIACNRLILLHGP 174
            |..:......|:...|....:..|.....::::                 |.       |||:||
  Rat   842 IGGLHEVRQILMDTIQLPAKYPELFANLPIRQR-----------------TG-------ILLYGP 882

  Fly   175 PGTGKTSLCKALAQKLSIRTQGSYAYTHLVEINSHSLFSKWFSESGKLVAQLFNKIAELVSDPNN 239
            ||||||.|...:|::..:         :.:.|....|.||:...|.:.|..:|  |....:.|
  Rat   883 PGTGKTLLAGVVARESGM---------NFISIQGPELLSKYIGASEQAVRDVF--IRAQAAKP-- 934

  Fly   240 LVCVL-IDEVESLAYARSAMSSNEPRDAMRVVNAVLTQLDSLKTCPNVLILATSNLAQSIDLAFV 303
              |:| .||.||:| .|....:....|  ||||.:|||||.::....|.:||.::....||.|.:
  Rat   935 --CILFFDEFESIA-PRRGHDNTGVTD--RVVNQLLTQLDGVEGLQGVYVLAATSRPDLIDPALL 994

  Fly   304 --DRADIRLFIGYPGISAIREIYKGMLAELMSAGVLQREVLESEDAEEGLLTQLAERSVGLSGRT 366
              .|.|..::...|          ..::.|....||.:.:..::|.:...:..:.|...|...:.
  Rat   995 RPGRLDKCVYCPPP----------DQVSRLEILTVLSKSLPLADDVDLQHVASVTESFTGADLKA 1049

  Fly   367 L-----------RKLPLLAHAQYTSSTLFELDQKISLSD--FLDAML----EALEQHLG-EQRLL 413
            |           |.||...|...:||     |..:|||.  ||:...    .|.:...| :|.|:
  Rat  1050 LLYNAQLEALQGRLLPGGLHDGGSSS-----DSDLSLSSMVFLNHSSGSDDSAGDGECGLDQSLV 1109

  Fly   414 KLESMEQL 421
            .||..|.|
  Rat  1110 SLEMSEIL 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_001287235.1	AAA	166..315	CDD:214640	48/151 (32%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	48/147 (33%)
Pex1	NP_001102690.1	PEX-2N	19..98	CDD:286362
		PEX-1N	104..179	CDD:286361
		AAA	591..741	CDD:214640	4/18 (22%)
		AAA	595..724	CDD:278434	1/1 (100%)
		AAA	877..1009	CDD:214640	49/159 (31%)
		AAA	877..1006	CDD:278434	48/146 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900