Protein Alignment pch2 and NVL

DIOPT Version :10

• Sequence 1: NP_524282.4
• Gene: pch2 / 41013
• FlyBaseID: FBgn0051453
• Length: 421
• Species: Drosophila melanogaster
• Sequence 2: XP_016856867.1
• Gene: NVL / 4931
• HGNCID: 8070
• Length: 917
• Species: Homo sapiens
• Alignment Length: 307
• Identity: 83/307 - (27%)
• Similarity: 136/307 - (44%)
• Gaps: 59/307 - (19%)

  Fly    31 ETALKAYFQTARKLPRNVSFLPDLTAEQTEHVHSVLLERDNGGVQPLKVAETKFRFHFYATRPEE 95
            |.|:.|..:...||.......|::     |.:.|..::.:..|.:|  .:||:          :|
Human   541 EAAMCAVNRVLMKLQEQQKKNPEM-----EDLPSKGVQEERLGTEP--TSETQ----------DE 588

  Fly    96 GQ--LGLFS-----GEEGSDGI-----DSIVAASHALLPAAQFVGL-------WENLIYETGLKE 141
            .|  |||..     .||...|:     |.|||.| ::.|:|:..|.       |.::.....::|
Human   589 LQRLLGLLRDQDPLSEEQMQGLCIELNDFIVALS-SVQPSAKREGFVTVPNVTWADIGALEDIRE 652

  Fly   142 KLLKFALSALMFSEHRVDTNVIACNRLILLHGPPGTGKTSLCKALAQKLSIRTQGSYAYTHLVEI 206
            : |..|:.|.:.:..:.....:.....:||.||||.|||.|.||:|.:..:         :.:.:
Human   653 E-LTMAILAPVRNPDQFKALGLVTPAGVLLAGPPGCGKTLLAKAVANESGL---------NFISV 707

  Fly   207 NSHSLFSKWFSESGKLVAQLFNKIAELVSDPNNLVCVL-IDEVESLAYARSAMSSNEPRDAMRVV 270
            ....|.:.:..||.:.|.|:|.:.      .|:..||: .|||::|...|   |..|...::|||
Human   708 KGPELLNMYVGESERAVRQVFQRA------KNSAPCVIFFDEVDALCPRR---SDRETGASVRVV 763

  Fly   271 NAVLTQLDSLKTCPNVLILATSNLAQSIDLAFV--DRADIRLFIGYP 315
            |.:||::|.|:....|.|:|.:|....||.|.:  .|.|..||:|.|
Human   764 NQLLTEMDGLEARQQVFIMAATNRPDIIDPAILRPGRLDKTLFVGLP 810

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_524282.4	RecA-like_Pch2-like	115..312	CDD:410916	57/206 (28%)
NVL	XP_016856867.1	Nucleolin_bd	2..72	CDD:465247
		CDC48	<277..917	CDD:273521	83/307 (27%)