Protein Alignment pch2 and FIGNL2

DIOPT Version :10

• Sequence 1: NP_524282.4
• Gene: pch2 / 41013
• FlyBaseID: FBgn0051453
• Length: 421
• Species: Drosophila melanogaster
• Sequence 2: XP_016874787.1
• Gene: FIGNL2 / 401720
• HGNCID: 13287
• Length: 767
• Species: Homo sapiens
• Alignment Length: 346
• Identity: 85/346 - (24%)
• Similarity: 137/346 - (39%)
• Gaps: 60/346 - (17%)

  Fly    72 GGVQPLKV---------AETKFRFHFYATRPEEGQLGLFSGE--EGSD--GIDSIVAASHALLPA 123
            ||..||||         .|...:|...|..| .|...:.|||  :|.|  .::.:.:......|.
Human   439 GGGVPLKVLGSPVYGPQLEPFEKFPERAPAP-RGGFAVPSGETPKGVDPGALELVTSKMVDCGPP 502

  Fly   124 AQFVGLWENLIYETGLKEKLLKFALSALMFSEHRVDTNVIACNRLILLHGPPGTGKTSLCKALAQ 188
            .|:..:......:..|:|:|:...|....:      ...:...|.:||.||.|.||..|.:.||.
Human   503 VQWADVAGQGALKAALEEELVWPLLRPPAY------PGSLRPPRTVLLFGPRGAGKALLGRCLAT 561

  Fly   189 KLSIRTQGSYAYTHLVEINSHSLFSKWFSESGKLVAQLFNKIAELVSDPNNLVCVLIDEVESLAY 253
            :|.         ..|:.:...:|.:...:|..:|:...|  .|.....|:.|   ||.|:|:|..
Human   562 QLG---------ATLLRLRGATLAAPGAAEGARLLQAAF--AAARCRPPSVL---LISELEALLP 612

  Fly   254 ARSAMSSNEPRDAMRVVNAVLTQLDSLKTC----PNVLILATSNLAQSIDLAFVDRADIRLFIGY 314
            ||.  .......|::|  .:|..||.  .|    ..||::.|::...::|.|...|..:|.::..
Human   613 ARD--DGAAAGGALQV--PLLACLDG--GCGAGADGVLVVGTTSRPAALDEATRRRFSLRFYVAL 671

  Fly   315 PGISAIREIYKGMLAELMSAGVLQREVLESEDAEEGLLTQLAERSVGLSGRTLRKLPLLAHAQYT 379
            |...|..:|.:..||: ....:.:||           |..|.:.:.|.||..|.:|...|.|
Human   672 PDSPARGQILQRALAQ-QGCALSERE-----------LAALVQGTQGFSGGELGQLCQQAAA--- 721

  Fly   380 SSTLFELDQKISLSDFLDAML 400
            .:.|..|.:.:|..| |:|.|
Human   722 GAGLPGLQRPLSYKD-LEAAL 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_524282.4	RecA-like_Pch2-like	115..312	CDD:410916	46/200 (23%)
FIGNL2	XP_016874787.1	RecA-like_fidgetin	507..669	CDD:410931	44/187 (24%)
		HflB	<643..>720	CDD:440233	21/88 (24%)