DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pch2 and Spast

DIOPT Version :9

Sequence 1:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_008762708.1	Gene:	Spast / 362700	RGDID:	1308494	Length:	614	Species:	Rattus norvegicus

Alignment Length:	286	Identity:	79/286 - (27%)
Similarity:	128/286 - (44%)	Gaps:	45/286 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 EKLLKFALSALMF---SEHRVDTNVIACNRLILLHGPPGTGKTSLCKALAQKLSIRTQGSYAYTH 202
            ::|.|.||..::.   ....:.|.:.|..|.:||.||||.|||.|.||:|.:         :...
  Rat   345 QELAKQALQEIVILPSLRPELFTGLRAPARGLLLFGPPGNGKTMLAKAVAAE---------SNAT 400

  Fly   203 LVEINSHSLFSKWFSESGKLVAQLFNKIAELVSDPNNLVCVLIDEVESLAYARSAMSSNEPRDAM 267
            ...|::.||.||:..|..|||..||....||  .|:   .:.||||:||...|   ...|...:.
  Rat   401 FFNISAASLTSKYVGEGEKLVRALFAVAREL--QPS---IIFIDEVDSLLCER---REGEHDASR 457

  Fly   268 RVVNAVLTQLDSLKTC--PNVLILATSNLAQSIDLAFVDRADIRLFIGYPGISAIREIYKGMLAE 330
            |:....|.:.|.:::.  ..||::..:|..|.:|.|.:.|...|:::..|.......:.|.:|.:
  Rat   458 RLKTEFLIEFDGVQSAGDDRVLVMGATNRPQELDEAVLRRFIKRVYVSLPNEETRLLLLKNLLCK 522

  Fly   331 LMSAGVLQREVLESEDAEEGLLTQLAERSVGLSGRTLRKL-------PL--LAHAQYTSSTLFEL 386
             ..:.:.|:|           |.|||..:.|.||..|..|       |:  |...|..:.:..|:
  Rat   523 -QGSPLTQKE-----------LAQLARMTDGYSGSDLTALAKDAALGPIRELKPEQVKNMSASEM 575

  Fly   387 DQKISLSDFLDAMLEALEQHLGEQRL 412
             :.|.||||.:: |:.:::.:..|.|
  Rat   576 -RNIRLSDFTES-LKKIKRSVSPQTL 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_001287235.1	AAA	166..315	CDD:214640	47/150 (31%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	46/146 (32%)
Spast	XP_008762708.1	MIT_spastin	114..193	CDD:239142
		P-loop_NTPase	339..>395	CDD:304359	19/49 (39%)
		AAA	372..508	CDD:214640	47/152 (31%)
		AAA	376..506	CDD:278434	46/146 (32%)
		Vps4_C	<578..610	CDD:286426	8/23 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900