DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pch2 and vcp

DIOPT Version :9

Sequence 1:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_958889.1	Gene:	vcp / 327197	ZFINID:	ZDB-GENE-030131-5408	Length:	806	Species:	Danio rerio

Alignment Length:	245	Identity:	65/245 - (26%)
Similarity:	108/245 - (44%)	Gaps:	46/245 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 LWENLIYETGLKEKLLKFALSALMFSEHRVDTNVIACNRLILLHGPPGTGKTSLCKALAQKLSIR 193
            |.|.:.|.....:|.|||.::.               ::.:|.:||||.|||.|.||:|.:
Zfish   489 LQELVQYPVEHPDKFLKFGMTP---------------SKGVLFYGPPGCGKTLLAKAIANE---- 534

  Fly   194 TQGSYAYTHLVEINSHSLFSKWFSESGKLVAQLFNKIAELVSDPNNLVCVL-IDEVESLAYARSA 257
                 ...:.:.|....|.:.||.||...|.::|:|..:...      ||| .||::|:|.||..
Zfish   535 -----CQANFISIKGPELLTMWFGESEANVREIFDKARQAAP------CVLFFDELDSIAKARGG 588

  Fly   258 MSSNEPRDAMRVVNAVLTQLDSLKTCPNVLILATSNLAQSIDLAFV--DRADIRLFIGYPGISAI 320
            ...:....|.||:|.:||::|.:.:..||.|:..:|....||.|.:  .|.|..::|..|.
Zfish   589 NVGDGGGAADRVINQILTEMDGMSSKKNVFIIGATNRPDIIDPAILRPGRLDQLIYIPLPD---- 649

  Fly   321 REIYKGMLAELMSAGVLQREVLESEDAEEGLLTQLAERSVGLSGRTLRKL 370
                     |.....:|:..:.:|..:::..|..||:.:.|.||..|.::
Zfish   650 ---------EKSRIAILKANLRKSPISKDVDLDFLAKMTNGFSGADLTEI 690

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_001287235.1	AAA	166..315	CDD:214640	47/151 (31%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	47/147 (32%)
vcp	NP_958889.1	CDC48	25..764	CDD:273521	65/245 (27%)
		CDC48_N	25..107	CDD:280513
		CDC48_2	131..191	CDD:215011
		AAA	241..370	CDD:278434
		P-loop_NTPase	452..>534	CDD:304359	19/59 (32%)
		AAA	514..647	CDD:278434	47/147 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	708..727
		Vps4_C	<718..760	CDD:286426
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	768..806
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810