DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pch2 and Nvl

DIOPT Version :9

Sequence 1:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	NP_001099450.1	Gene:	Nvl / 289323	RGDID:	1311270	Length:	855	Species:	Rattus norvegicus

Alignment Length:	355	Identity:	100/355 - (28%)
Similarity:	147/355 - (41%)	Gaps:	86/355 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 EVCLRGNDLRSNAIRNNVETALKAYFQT-ARK--LPRNVSFL-----------PDLTAEQTE--- 60
            ||||...|          |.:.:...|| .||  ||...:|.           .||.|...|
  Rat   428 EVCLGIPD----------EASRERILQTLCRKLRLPETFNFSHLAHLTPGFVGADLMALCREAAV 482

  Fly    61 -HVHSVLLER--------DNGGVQPLKVAETKFRFHFYATRPEEGQ------LGLFS-----GEE 105
             .||.||:.|        :.||:.    ::.:......|..|.|.|      |||..     .||
  Rat   483 CAVHRVLMRRQEQQRTEPETGGLP----SDGEQGRSLGAEPPSETQDELQRLLGLLRDQDPISEE 543

  Fly   106 GSDGI-----DSIVAASHALLPAAQFVGL-------WENLIYETGLKEKLLKFALSALMFSEHRV 158
            ...|:     |.|||.|. :.|:|:..|.       |.::.....::|:|....|:.:...|...
  Rat   544 QMQGLCLELNDFIVALSE-VQPSAKREGFVTVPNVTWADVGALEDIREELTMAILAPVRNPEQFR 607

  Fly   159 DTNVIACNRLILLHGPPGTGKTSLCKALAQKLSIRTQGSYAYTHLVEINSHSLFSKWFSESGKLV 223
            ...::| ...:||.||||.|||.|.||:|.:..:         :.:.:....|.:.:..||.:.|
  Rat   608 ALGLVA-PAGVLLAGPPGCGKTLLAKAVANESGL---------NFISVKGPELLNMYVGESERAV 662

  Fly   224 AQLFNKIAELVSDPNNLVCVL-IDEVESLAYARSAMSSNEPRDAMRVVNAVLTQLDSLKTCPNVL 287
            .|:|.:.      .|:..||: .|||::|...|   |..|...::||||.:||::|.|:|...|.
  Rat   663 RQVFQRA------KNSAPCVIFFDEVDALCPRR---SDRETGASVRVVNQLLTEMDGLETRQQVF 718

  Fly   288 ILATSNLAQSIDLAFV--DRADIRLFIGYP 315
            |||.:|....||.|.:  .|.|..||:|.|
  Rat   719 ILAATNRPDIIDPAILRPGRLDKTLFVGLP 748

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_001287235.1	AAA	166..315	CDD:214640	51/151 (34%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	50/147 (34%)
Nvl	NP_001099450.1	Nucleolin_bd	2..71	CDD:406995
Nvl	NP_001099450.1	CDC48	<255..855	CDD:273521	100/355 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900