DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pch2 and SPATA5

DIOPT Version :9

Sequence 1:	NP_001287235.1	Gene:	pch2 / 41013	FlyBaseID:	FBgn0051453	Length:	421	Species:	Drosophila melanogaster
Sequence 2:	XP_016863314.1	Gene:	SPATA5 / 166378	HGNCID:	18119	Length:	917	Species:	Homo sapiens

Alignment Length:	392	Identity:	98/392 - (25%)
Similarity:	149/392 - (38%)	Gaps:	133/392 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 ASHALLPAAQFVGLWENLIYE--TGLK----------------EKLLKFALSA------------ 150
            ||..||...|..|....|:.|  ||||                |:||||::.|
Human   264 ASDVLLDVTQSPGDGSGLMLEEVTGLKCNFESAREGNEQLTEEERLLKFSIGAKCNTDTFYFISS 328

  Fly   151 ---LMFSEHRVDTNV------------------------------------------IACNRLIL 170
               :.|:|  :|.|.                                          |...|.:|
Human   329 TTRVNFTE--IDKNSKEQDNQFKVTYDMIGGLSSQLKAIREIIELPLKQPELFKSYGIPAPRGVL 391

  Fly   171 LHGPPGTGKTSLCKALAQKLSIRTQGSYAYTHLVEINSHSLFSKWFSESGKLVAQLFNKIAELVS 235
            |:||||||||.:.:|:|.::     |:|...    ||...:.||::.|:...:.|:|.:..  :.
Human   392 LYGPPGTGKTMIARAVANEV-----GAYVSV----INGPEIISKFYGETEAKLRQIFAEAT--LR 445

  Fly   236 DPNNLVCVLIDEVESLAYARSAMSSNEPRDAMRVVNAVLTQLDSLKTCPN---VLILATSNLAQS 297
            .|:   .:.|||:::|...|.. :.||..  .|||.::||.:|.:.:..:   ||:|..:|...:
Human   446 HPS---IIFIDELDALCPKREG-AQNEVE--KRVVASLLTLMDGIGSEVSEGQVLVLGATNRPHA 504

  Fly   298 IDLAF--VDRADIRLFIGYPGISAIREIYKGMLAE----LMSAGVLQ------------REVLES 344
            :|.|.  ..|.|..:.||.|......:|.:.:|..    |..|.:||            .:||.:
Human   505 LDAALRRPGRFDKEIEIGVPNAQDRLDILQKLLRRVPHLLTEAELLQLANSAHGYVGADLKVLCN 569

  Fly   345 EDAEEGLL----------TQLAERSVGLSG--RTLRKLPLLAHAQYTSSTLFELDQKISLSDFLD 397
            |.|...:|          |.|.:...||..  |.|:|.|.|...:.....      ||:|.|||.
Human   570 EAAGTRILKAHMYVSAFATGLTQTPQGLCALRRILKKQPNLPDVKVAGLV------KITLKDFLQ 628

  Fly   398 AM 399
            ||
Human   629 AM 630

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pch2	NP_001287235.1	AAA	166..315	CDD:214640	46/153 (30%)
pch2	NP_001287235.1	AAA	169..314	CDD:278434	44/149 (30%)
SPATA5	XP_016863314.1	CDC48_N	65..133	CDD:389870
SPATA5	XP_016863314.1	CDC48	<323..913	CDD:273521	80/333 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0464
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900