Protein Alignment CG31259 and TMEM135

DIOPT Version :9

• Sequence 1: NP_001287233.1
• Gene: CG31259 / 41010
• FlyBaseID: FBgn0051259
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_075069.3
• Gene: TMEM135 / 65084
• HGNCID: 26167
• Length: 458
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 152/481 - (31%)
• Similarity: 232/481 - (48%)
• Gaps: 62/481 - (12%)

  Fly     1 MGAQSKLAEIALNCTCYEYHHPWTKSCACAAAGMMISEIPPSLRTYATVYVFALIMRGRIPSLKD 65
            |.|.||    ::...|||..|.|..||..:...:....:..||:.||.:|:.|.|:|.|.....
Human     1 MAALSK----SIPHNCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKRKLDYY- 60

  Fly    66 LRRTASGILQSTAFLSMNGGLFVFAVCYLRQILGGFYFGTVAWLPSF----LASFACLAFERPER 126
            |.:....||||.:||:.||.|::...|.||:|||.||    :|.|.|    .||:..:..||..|
Human    61 LHKLLPEILQSASFLTANGALYMAFFCILRKILGKFY----SWTPGFGAALPASYVAILIERKSR 121

  Fly   127 RAPLALYVANVGIETLWKMMEARGWVRSIPNGQVFIMGASVTALMYLY----RAGLHKTVAKDPT 187
            |..|.:|:||:..|||::|..|||.:.::.||:|.:.  .:||.||::    :.||     |..|
Human   122 RGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLF--CITAAMYMFFFRCKDGL-----KGFT 179

  Fly   188 FKAIALIVGKEDEGPLKT--------PVVTTTQSSRQAPLNFQSISAYVQLYDRMLK--AKHPSC 242
            |.|:..||||| |.|..:        .|....:...:.|.....|....:..|.:.|  .:|..|
Human   180 FSALRFIVGKE-EIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRCC 243

  Fly   243 PH-KRGCVPYALIGGLKPFLGGVGLSVG--LKLLLNIPKIFKSKMQWRKHIF-----------NG 293
            .| :..|:.|.:.|.::.|      |||  ::..|.||..|       :|:|           |.
Human   244 KHYEDNCISYCIKGFIRMF------SVGYLIQCCLRIPSAF-------RHLFTQPSRLLSLFYNK 295

  Fly   294 GSLQLGLALGIFSFLFKSTTCGLRHTFGFDNALFAIPAGLIGSIGFFRFPNTTVACYLMWKSMHL 358
            .:.|||..||.|..::|.|:|.||.....|:.|.||.||.:..|....:.:||::.||..|.:..
Human   296 ENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVET 360

  Fly   359 LYNWGIAEGKLPEVPHFAMLMYGFFTAVLFHSAILEARSLRPSYYKFLMGISGNRISRFNVKPFE 423
            :|..||..||:|..||...::|...||:.|.:|::|.::|||||:|||:.::..:.:..|.|..:
Human   361 MYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLD 425

  Fly   424 AYGLKSQDQINYVIKKLGIDMTSPFP 449
            .:|..:.......|.:|....|:..|
Human   426 VFGTGASKHFQDFIPRLDPRYTTVTP 451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31259	NP_001287233.1	TMEM135_C_rich	15..145	CDD:292604	50/133 (38%)
TMEM135	NP_075069.3	TMEM135_C_rich	9..142	CDD:292604	51/137 (37%)
		Tim17	249..>338	CDD:280604	31/101 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144502
Domainoid	1	1.000	87	1.000	Domainoid score	I7989
eggNOG	1	0.900	-	-		E1_KOG1398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11295
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3508
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49433
OrthoDB	1	1.010	-	-		D378483at33208
OrthoFinder	1	1.000	-	-		FOG0004145
OrthoInspector	1	1.000	-	-		otm41501
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12459
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5452
SonicParanoid	1	1.000	-	-		X3968
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.900