DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31259 and tmem135

DIOPT Version :9

Sequence 1:	NP_001287233.1	Gene:	CG31259 / 41010	FlyBaseID:	FBgn0051259	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001082887.1	Gene:	tmem135 / 568244	ZFINID:	ZDB-GENE-070424-70	Length:	465	Species:	Danio rerio

Alignment Length:	480	Identity:	145/480 - (30%)
Similarity:	237/480 - (49%)	Gaps:	71/480 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGAQSKLAEIALNCTCYEYHHPWTKSCACAAAGMMISEIPPSLRTYATVYVFALIMRGRIPSLKD 65
            |.|.||    ::..:|||..|.|:.||..:...:....:..|.:.||.:|:.|.|:|.|   .||
Zfish     1 MAALSK----SIPHSCYELGHTWSSSCTASTLQVTAGALEVSFKIYAPLYLIAAILRRR---KKD 58

  Fly    66 L--RRTASGILQSTAFLSMNGGLFVFAVCYLRQILGGFYFGTVAWLPSFLASFACLAFERPERRA 128
            .  :|....|||||:||:.||||::...|.||::||.||..:..:..:..||:..:..||..||.
Zfish    59 YYKKRLLPEILQSTSFLTANGGLYIAFFCILRRLLGRFYSWSAGFGAALPASYIAILIERKSRRG 123

  Fly   129 PLALYVANVGIETLWKMMEARGWVRSIPNGQVFIMGASVTALMYLYRA--GLHKTVAKDPTFKAI 191
            .|.:|:||:..||:::|...||.|:.:.:|:|.:...:.:..|:.:|.  ||:..     .|.|:
Zfish   124 LLTIYMANLATETIFRMAVTRGLVKPMKHGEVLLFCLTASLYMFFFRCKDGLNGF-----AFSAL 183

  Fly   192 ALIVGKE------------------------DEGPLKTPVVTTTQSSRQAPLNFQSISAYV-QLY 231
            ..|||||                        :|.|.:||      :||.:     .|.|:. :|.
Zfish   184 KFIVGKEEIPTHSCLAEHAYGQGSERDVQPAEERPEQTP------ASRGS-----CIRAFARKLL 237

  Fly   232 DRMLK--AKHPSCPHKR-GCVPYALIGGLKPFLGGVGLSVG--LKLLLNIPKIFK------SKMQ 285
            |.:.|  .:|..|.|.: .|:.|.:.|.::.|      |||  ::..|.:|..|:      |::.
Zfish   238 DSLCKHGPRHRCCKHHQDNCISYCVKGFIRMF------SVGYLIQCCLKVPSAFRQAFTKPSRLL 296

  Fly   286 WRKHIFNGGSLQLGLALGIFSFLFKSTTCGLRHTFGFDNALFAIPAGLIGSIGFFRFPNTTVACY 350
            |.  ::|..:.|||..||.|..::|.|:|.||.....|:.|.|:.||.:.....|.:.:||::.|
Zfish   297 WL--LYNKENFQLGAFLGSFVSIYKGTSCLLRWMRNLDDELHALIAGFLAGTSMFFYKSTTISMY 359

  Fly   351 LMWKSMHLLYNWGIAEGKLPEVPHFAMLMYGFFTAVLFHSAILEARSLRPSYYKFLMGISGNRIS 415
            |..|.:..||..||..|:.|.:|....::|...||:.|.:|::|.::|||||:|||:.::..|.:
Zfish   360 LFSKLVETLYFKGIEAGRFPYLPEADTVIYAISTAICFQAAVMEVQNLRPSYWKFLLRLTKGRFA 424

  Fly   416 RFNVKPFEAYGLKSQDQINYVIKKL 440
            ..|.|..:.:|.::.........||
Zfish   425 LMNRKVLDVFGTEASKNFGNFTPKL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31259	NP_001287233.1	TMEM135_C_rich	15..145	CDD:292604	48/131 (37%)
tmem135	NP_001082887.1	TMEM135_C_rich	9..142	CDD:292604	49/135 (36%)
tmem135	NP_001082887.1	Tim17	256..>345	CDD:280604	29/96 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577628
Domainoid	1	1.000	99	1.000	Domainoid score	I7011
eggNOG	1	0.900	-	-		E1_KOG1398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11295
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3403
OMA	1	1.010	-	-		QHG49433
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004145
OrthoInspector	1	1.000	-	-		otm25479
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12459
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5452
SonicParanoid	1	1.000	-	-		X3968
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.890