DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31259 and Tmem135

DIOPT Version :9

Sequence 1:	NP_001287233.1	Gene:	CG31259 / 41010	FlyBaseID:	FBgn0051259	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001013918.1	Gene:	Tmem135 / 293098	RGDID:	1309948	Length:	458	Species:	Rattus norvegicus

Alignment Length:	473	Identity:	153/473 - (32%)
Similarity:	236/473 - (49%)	Gaps:	64/473 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGAQSKLAEIALNCTCYEYHHPWTKSCACAAAGMMISEIPPSLRTYATVYVFALIMRGRIPSLK- 64
            |.|.||    ::...|||..|.|..||..:...:....:..|||.||.:|:.|.::|.|  .|:
  Rat     1 MAALSK----SIPHNCYEIGHTWNPSCRVSFLQITWGALEESLRIYAPLYLIAAVLRKR--KLEY 59

  Fly    65 DLRRTASGILQSTAFLSMNGGLFVFAVCYLRQILGGFYFGTVAWLPSF----LASFACLAFERPE 125
            .|.:....||||.:||:.||.|::...|.||:|||.||    :|.|.|    .||:..:..||..
  Rat    60 YLYKLLPEILQSASFLTANGALYITFFCVLRKILGKFY----SWTPGFGAALPASYVAILIERKS 120

  Fly   126 RRAPLALYVANVGIETLWKMMEARGWVRSIPNGQVFIMGASVTALMYLY----RAGLHKTVAKDP 186
            ||..|.:|:||:..|||::|..|||.:.::.||:|.:.  .:||.||::    :.||     |..
  Rat   121 RRGLLTIYMANLATETLFRMGVARGTITTLRNGEVLLF--CITAAMYMFFFRCKDGL-----KGF 178

  Fly   187 TFKAIALIVGKEDEGPLKT-------PVVTTTQSSRQAPLNFQSISAYVQ-LYDRMLK--AKHPS 241
            ||.|:..||||| |.|..:       ..|...:...:......|:.|.|: |.|.:.|  .:|..
  Rat   179 TFSALRFIVGKE-EIPTHSYSPETAYAKVEQKREKHRGTTRAMSLIALVRSLVDSICKHGPRHRC 242

  Fly   242 CPH-KRGCVPYALIGGLKPFLGGVGLSVG--LKLLLNIPKIFKSKMQWRKHIF-----------N 292
            |.| :..|:.|.:.|.::.|      |||  ::..|.||..|       :|:|           |
  Rat   243 CKHYEDNCISYCIKGFIRMF------SVGYLIQCCLRIPSAF-------RHLFTEPSRLLSLFYN 294

  Fly   293 GGSLQLGLALGIFSFLFKSTTCGLRHTFGFDNALFAIPAGLIGSIGFFRFPNTTVACYLMWKSMH 357
            ..:.|||..||.|..::|.|:|.||.....|:.|.||.||.:..:....:.:||::.||..|.:.
  Rat   295 KENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIVAGFLAGVSMMFYKSTTISMYLASKLVE 359

  Fly   358 LLYNWGIAEGKLPEVPHFAMLMYGFFTAVLFHSAILEARSLRPSYYKFLMGISGNRISRFNVKPF 422
            .:|..||..||:|..|....::|...||:.||:|::|.::|||||:|||:.::..|.:..|.|..
  Rat   360 TMYFKGIEAGKVPYFPQADTIIYSISTAICFHAAVMEVQNLRPSYWKFLLRLTKGRFALMNRKAL 424

  Fly   423 EAYGLKSQDQINYVIKKL 440
            :.:|..:..:.:..|.:|
  Rat   425 DVFGTGASREFHNFIPRL 442

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31259	NP_001287233.1	TMEM135_C_rich	15..145	CDD:292604	51/134 (38%)
Tmem135	NP_001013918.1	TMEM135_C_rich	9..142	CDD:292604	52/138 (38%)
Tmem135	NP_001013918.1	Tim17	249..>338	CDD:280604	31/101 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338210
Domainoid	1	1.000	89	1.000	Domainoid score	I7661
eggNOG	1	0.900	-	-		E1_KOG1398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11295
Inparanoid	1	1.050	236	1.000	Inparanoid score	I3309
OMA	1	1.010	-	-		QHG49433
OrthoDB	1	1.010	-	-		D378483at33208
OrthoFinder	1	1.000	-	-		FOG0004145
OrthoInspector	1	1.000	-	-		otm45616
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12459
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3968
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870