DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31259 and tmem135

DIOPT Version :9

Sequence 1:	NP_001287233.1	Gene:	CG31259 / 41010	FlyBaseID:	FBgn0051259	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	XP_002936590.2	Gene:	tmem135 / 100497844	XenbaseID:	XB-GENE-954105	Length:	454	Species:	Xenopus tropicalis

Alignment Length:	480	Identity:	152/480 - (31%)
Similarity:	232/480 - (48%)	Gaps:	82/480 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGAQSKLAEIALNCTCYEYHHPWTKSCACAAAGMMISEIPPSLRTYATVYVFALIMRGR------ 59
            |.|.||    ::..:|||..|.|..||..:...:....:..:.:.||.:|:.|.|:|.:
Frog     1 MAALSK----SIPHSCYEIGHTWNPSCFGSYLQITQGAMEEAFKIYAPLYLVAAILRRKNLDYYI 61

  Fly    60 ---IPSLKDLRRTASGILQSTAFLSMNGGLFVFAVCYLRQILGGFYFGTVAWLPSF----LASFA 117
               :|.|          ||||:||:.||.|::...|.||::||.|||    |.|.|    .||:|
Frog    62 HKLLPEL----------LQSTSFLTANGSLYIAFFCILRKLLGRFYF----WTPGFGAALPASYA 112

  Fly   118 CLAFERPERRAPLALYVANVGIETLWKMMEARGWVRSIPNGQVFIMGASVTALMYLY----RAGL 178
            .:..||..||..|.:|:||...|.|::|...||:::.|.:|:|.:.  .:||.:|::    |.||
Frog   113 AILIERKSRRGLLTIYMANQATEALFRMSVTRGYIKPIRHGEVLLF--CITAALYMFFFRCRDGL 175

  Fly   179 HKTVAKDPTFKAIALIVGKEDEGPLKTPV-------VTTTQSSRQAPLNFQSISAYVQLYDRMLK 236
                 |...|.|:..||||| |.|..|.|       ....:|..|..|:..||.   :|.|.:.|
Frog   176 -----KGFAFSALKFIVGKE-EIPAHTLVPESMYARAEEKKSKEQRGLSRSSIK---KLMDTICK 231

  Fly   237 --AKHPSCPH-KRGCVPYALIGGLKPFLGGVGLSVG--LKLLLNIPKIFKSKMQWRKHIF----- 291
              .:|..|.| :..|:.|.:.|.::.|      |:|  ::..|.||..|       :|:|
Frog   232 HGPRHRCCKHYEDNCISYCVKGFIRMF------SIGYLIQCCLRIPSTF-------RHLFTKPSR 283

  Fly   292 ------NGGSLQLGLALGIFSFLFKSTTCGLRHTFGFDNALFAIPAGLIGSIGFFRFPNTTVACY 350
                  |..:.|||..||.|..::|.|:|.||.....|:.|.||.||.:..|....:.:||::.|
Frog   284 LLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWVRNLDDELHAIVAGFLAGISMMFYKSTTISMY 348

  Fly   351 LMWKSMHLLYNWGIAEGKLPEVPHFAMLMYGFFTAVLFHSAILEARSLRPSYYKFLMGISGNRIS 415
            |..|.:..:|..||..||.|..||...::|...||:.||:|::|.::|||||:|||..::..|.:
Frog   349 LASKLVETMYFKGIEAGKCPYFPHADSVIYAVSTAICFHAAVMEVQNLRPSYWKFLQRLTKGRFA 413

  Fly   416 RFNVKPFEAYGLKSQDQINYVIKKL 440
            ..|.|..:.:..::....|..:.||
Frog   414 LMNRKALDVFDSEASKTFNNFVPKL 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31259	NP_001287233.1	TMEM135_C_rich	15..145	CDD:292604	48/142 (34%)
tmem135	XP_002936590.2	TMEM135_C_rich	9..142	CDD:374269	49/146 (34%)
tmem135	XP_002936590.2	Tim17	<295..347	CDD:367093	20/51 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	147	1.000	Domainoid score	I4467
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11295
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3309
OMA	1	1.010	-	-		QHG49433
OrthoDB	1	1.010	-	-		D378483at33208
OrthoFinder	1	1.000	-	-		FOG0004145
OrthoInspector	1	1.000	-	-		otm48709
Panther	1	1.100	-	-	O	PTHR12459
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3968
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080