DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11737 and TMEM135

DIOPT Version :9

Sequence 1:	NP_001262370.1	Gene:	CG11737 / 41009	FlyBaseID:	FBgn0037592	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_075069.3	Gene:	TMEM135 / 65084	HGNCID:	26167	Length:	458	Species:	Homo sapiens

Alignment Length:	484	Identity:	151/484 - (31%)
Similarity:	235/484 - (48%)	Gaps:	69/484 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGQSKLIDPLCITCKEFQHPWTDHCVSATAGILLSATPYCLRVYTIVYALSLLMRHRIPSRDD- 64
            ||..||.|..   .|.|..|.|...|..:...|...|....|::|..:|.::.::|.|   :.|
Human     1 MAALSKSIPH---NCYEIGHTWHPSCRVSFLQITGGALEESLKIYAPLYLIAAILRKR---KLDY 59

  Fly    65 -LRKTLLGIIQSTAFLVTNAYTFILYNCALRHMLGRYNFYTVAFVPCFLASFSAILVERPARRPL 128
             |.|.|..|:||.:||..|...::.:.|.||.:||::..:|..|.....||:.|||:||.:||.|
Human    60 YLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGL 124

  Fly   129 LTLYVANVATEALWKMAESRGWVRSVPNGQTLIFGVSMAALLYIYRTGTTKDSI----FNILRIF 189
            ||:|:||:|||.|::|..:||.:.::.||:.|:|.::.|..::.:|   .||.:    |:.||..
Human   125 LTIYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFR---CKDGLKGFTFSALRFI 186

  Fly   190 VGKEEAGPIVKSGPAVPGEQPAPDRRRPTVSFSTVSDWVRVYS---------------NLIR--- 236
            |||||.                     ||.|||..:.:.:|..               .|:|
Human   187 VGKEEI---------------------PTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFV 230

  Fly   237 -------AKHESCRH-QQSCIGYSLMGGIKPFVGGVGLQVALKLVMNVKRITAGKMPWKKMIFNR 293
                   .:|..|:| :.:||.|.:.|.|:.|..|..:|..|::....:.:.........:.:|:
Human   231 DSICKHGPRHRCCKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNK 295

  Fly   294 GTLQLGIFMGSFSFLYKSVSCLLRHSFNRDDARFAIPASLIASISFTQYPDNTVALYVMWKALQI 358
            ...|||.|:|||..:||..||.||...|.||...||.|..:|.||...|...|:::|:..|.::.
Human   296 ENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAIIAGFLAGISMMFYKSTTISMYLASKLVET 360

  Fly   359 LCTKGQEHGIVPHIPNFMLFLYSFFTAVLFHAGILEPKSLRPSYYKFLQAISGDRLSKFNLSAFD 423
            :..||.|.|.||:.|:....:||..||:.|.|.::|.::|||||:|||..::..:.:..|....|
Human   361 MYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRKVLD 425

  Fly   424 VFGLSSQQQALDTIKALNIVEKSSLPAYS 452
            |||..:.:...|.|..|:       |.|:
Human   426 VFGTGASKHFQDFIPRLD-------PRYT 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11737	NP_001262370.1	TMEM135_C_rich	14..145	CDD:292604	48/132 (36%)
TMEM135	NP_075069.3	TMEM135_C_rich	9..142	CDD:292604	49/138 (36%)
TMEM135	NP_075069.3	Tim17	249..>338	CDD:280604	29/88 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144501
Domainoid	1	1.000	87	1.000	Domainoid score	I7989
eggNOG	1	0.900	-	-		E1_KOG1398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11295
Inparanoid	1	1.050	225	1.000	Inparanoid score	I3508
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49433
OrthoDB	1	1.010	-	-		D378483at33208
OrthoFinder	1	1.000	-	-		FOG0004145
OrthoInspector	1	1.000	-	-		otm41501
orthoMCL	1	0.900	-	-		OOG6_105767
Panther	1	1.100	-	-	LDO	PTHR12459
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5452
SonicParanoid	1	1.000	-	-		X3968
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800