DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11737 and tmem135

DIOPT Version :9

Sequence 1:	NP_001262370.1	Gene:	CG11737 / 41009	FlyBaseID:	FBgn0037592	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001082887.1	Gene:	tmem135 / 568244	ZFINID:	ZDB-GENE-070424-70	Length:	465	Species:	Danio rerio

Alignment Length:	460	Identity:	149/460 - (32%)
Similarity:	244/460 - (53%)	Gaps:	49/460 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGQSKLIDPLCITCKEFQHPWTDHCVSATAGILLSATPYCLRVYTIVYALSLLMRHRIPSRDDL 65
            ||..||.|..   :|.|..|.|:..|.::|..:...|.....::|..:|.::.::|.|  .:|..
Zfish     1 MAALSKSIPH---SCYELGHTWSSSCTASTLQVTAGALEVSFKIYAPLYLIAAILRRR--KKDYY 60

  Fly    66 RKTLL-GIIQSTAFLVTNAYTFILYNCALRHMLGRYNFYTVAFVPCFLASFSAILVERPARRPLL 129
            :|.|| .|:|||:||..|...:|.:.|.||.:|||:..::..|.....||:.|||:||.:||.||
Zfish    61 KKRLLPEILQSTSFLTANGGLYIAFFCILRRLLGRFYSWSAGFGAALPASYIAILIERKSRRGLL 125

  Fly   130 TLYVANVATEALWKMAESRGWVRSVPNGQTLIFGVSMAALLYIYRTGTTKDSI----FNILRIFV 190
            |:|:||:|||.:::||.:||.|:.:.:|:.|:|.::.:..::.:|   .||.:    |:.|:..|
Zfish   126 TIYMANLATETIFRMAVTRGLVKPMKHGEVLLFCLTASLYMFFFR---CKDGLNGFAFSALKFIV 187

  Fly   191 GKEEAGPIVKSGPAVP----------GE------QPAPDR--RRPTVSFSTVSDWVR-VYSNLIR 236
            ||||          :|          |:      |||.:|  :.|....|.:..:.| :..:|.:
Zfish   188 GKEE----------IPTHSCLAEHAYGQGSERDVQPAEERPEQTPASRGSCIRAFARKLLDSLCK 242

  Fly   237 --AKHESCR-HQQSCIGYSLMGGIKPFVGGVGLQVALKLVMNVKR--ITAGKMPWKKMIFNRGTL 296
              .:|..|: ||.:||.|.:.|.|:.|..|..:|..||:....::  ....::.|  :::|:...
Zfish   243 HGPRHRCCKHHQDNCISYCVKGFIRMFSVGYLIQCCLKVPSAFRQAFTKPSRLLW--LLYNKENF 305

  Fly   297 QLGIFMGSFSFLYKSVSCLLRHSFNRDDARFAIPASLIASISFTQYPDNTVALYVMWKALQILCT 361
            |||.|:|||..:||..|||||...|.||...|:.|..:|..|...|...|:::|:..|.::.|..
Zfish   306 QLGAFLGSFVSIYKGTSCLLRWMRNLDDELHALIAGFLAGTSMFFYKSTTISMYLFSKLVETLYF 370

  Fly   362 KGQEHGIVPHIPNFMLFLYSFFTAVLFHAGILEPKSLRPSYYKFLQAISGDRLSKFNLSAFDVFG 426
            ||.|.|..|::|.....:|:..||:.|.|.::|.::|||||:|||..::..|.:..|....||||
Zfish   371 KGIEAGRFPYLPEADTVIYAISTAICFQAAVMEVQNLRPSYWKFLLRLTKGRFALMNRKVLDVFG 435

  Fly   427 LSSQQ 431
            ..:.:
Zfish   436 TEASK 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11737	NP_001262370.1	TMEM135_C_rich	14..145	CDD:292604	48/131 (37%)
tmem135	NP_001082887.1	TMEM135_C_rich	9..142	CDD:292604	49/137 (36%)
tmem135	NP_001082887.1	Tim17	256..>345	CDD:280604	31/90 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577627
Domainoid	1	1.000	99	1.000	Domainoid score	I7011
eggNOG	1	0.900	-	-		E1_KOG1398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11295
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3403
OMA	1	1.010	-	-		QHG49433
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004145
OrthoInspector	1	1.000	-	-		otm25479
orthoMCL	1	0.900	-	-		OOG6_105767
Panther	1	1.100	-	-	LDO	PTHR12459
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5452
SonicParanoid	1	1.000	-	-		X3968
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.790