DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11737 and Tmem135

DIOPT Version :9

Sequence 1:	NP_001262370.1	Gene:	CG11737 / 41009	FlyBaseID:	FBgn0037592	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_001013918.1	Gene:	Tmem135 / 293098	RGDID:	1309948	Length:	458	Species:	Rattus norvegicus

Alignment Length:	470	Identity:	154/470 - (32%)
Similarity:	237/470 - (50%)	Gaps:	41/470 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGQSKLIDPLCITCKEFQHPWTDHCVSATAGILLSATPYCLRVYTIVYALSLLMRHRIPSRDDL 65
            ||..||.|..   .|.|..|.|...|..:...|...|....||:|..:|.::.::|.| .....|
  Rat     1 MAALSKSIPH---NCYEIGHTWNPSCRVSFLQITWGALEESLRIYAPLYLIAAVLRKR-KLEYYL 61

  Fly    66 RKTLLGIIQSTAFLVTNAYTFILYNCALRHMLGRYNFYTVAFVPCFLASFSAILVERPARRPLLT 130
            .|.|..|:||.:||..|...:|.:.|.||.:||::..:|..|.....||:.|||:||.:||.|||
  Rat    62 YKLLPEILQSASFLTANGALYITFFCVLRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLT 126

  Fly   131 LYVANVATEALWKMAESRGWVRSVPNGQTLIFGVSMAALLYIYRTGTTKDSI----FNILRIFVG 191
            :|:||:|||.|::|..:||.:.::.||:.|:|.::.|..::.:|   .||.:    |:.||..||
  Rat   127 IYMANLATETLFRMGVARGTITTLRNGEVLLFCITAAMYMFFFR---CKDGLKGFTFSALRFIVG 188

  Fly   192 KEEAGPIVKSGPA---VPGEQPAPDRRRPTVSFSTVSDWVRVYSNLIRA----------KHESCR 243
            |||. |.....|.   ...||.....|..|.:.|.::        |:|:          :|..|:
  Rat   189 KEEI-PTHSYSPETAYAKVEQKREKHRGTTRAMSLIA--------LVRSLVDSICKHGPRHRCCK 244

  Fly   244 H-QQSCIGYSLMGGIKPFVGGVGLQVALKLVMNVKRITAGKMPWKKMIFNRGTLQLGIFMGSFSF 307
            | :.:||.|.:.|.|:.|..|..:|..|::....:.:.........:.:|:...|||.|:|||..
  Rat   245 HYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTEPSRLLSLFYNKENFQLGAFLGSFVS 309

  Fly   308 LYKSVSCLLRHSFNRDDARFAIPASLIASISFTQYPDNTVALYVMWKALQILCTKGQEHGIVPHI 372
            :||..||.||...|.||...||.|..:|.:|...|...|:::|:..|.::.:..||.|.|.||:.
  Rat   310 IYKGTSCFLRWIRNLDDELHAIVAGFLAGVSMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYF 374

  Fly   373 PNFMLFLYSFFTAVLFHAGILEPKSLRPSYYKFLQAISGDRLSKFNLSAFDVFGLSSQQQALDTI 437
            |.....:||..||:.|||.::|.::|||||:|||..::..|.:..|..|.||||..:.::..:.|
  Rat   375 PQADTIIYSISTAICFHAAVMEVQNLRPSYWKFLLRLTKGRFALMNRKALDVFGTGASREFHNFI 439

  Fly   438 KALNIVEKSSLPAYS 452
            ..|:       |.|:
  Rat   440 PRLD-------PRYT 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11737	NP_001262370.1	TMEM135_C_rich	14..145	CDD:292604	49/130 (38%)
Tmem135	NP_001013918.1	TMEM135_C_rich	9..142	CDD:292604	50/136 (37%)
Tmem135	NP_001013918.1	Tim17	249..>338	CDD:280604	29/88 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166338209
Domainoid	1	1.000	89	1.000	Domainoid score	I7661
eggNOG	1	0.900	-	-		E1_KOG1398
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11295
Inparanoid	1	1.050	236	1.000	Inparanoid score	I3309
OMA	1	1.010	-	-		QHG49433
OrthoDB	1	1.010	-	-		D378483at33208
OrthoFinder	1	1.000	-	-		FOG0004145
OrthoInspector	1	1.000	-	-		otm45616
orthoMCL	1	0.900	-	-		OOG6_105767
Panther	1	1.100	-	-	LDO	PTHR12459
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3968
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770