DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG11737 and tmem135

DIOPT Version :9

Sequence 1:	NP_001262370.1	Gene:	CG11737 / 41009	FlyBaseID:	FBgn0037592	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	XP_002936590.2	Gene:	tmem135 / 100497844	XenbaseID:	XB-GENE-954105	Length:	454	Species:	Xenopus tropicalis

Alignment Length:	462	Identity:	148/462 - (32%)
Similarity:	246/462 - (53%)	Gaps:	25/462 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MAGQSKLIDPLCITCKEFQHPWTDHCVSATAGILLSATPYCLRVYTIVYALSLLMRHRIPSRD-D 64
            ||..||.|..   :|.|..|.|...|..:...|...|.....::|..:|.::.::|.:  :.| .
Frog     1 MAALSKSIPH---SCYEIGHTWNPSCFGSYLQITQGAMEEAFKIYAPLYLVAAILRRK--NLDYY 60

  Fly    65 LRKTLLGIIQSTAFLVTNAYTFILYNCALRHMLGRYNFYTVAFVPCFLASFSAILVERPARRPLL 129
            :.|.|..::|||:||..|...:|.:.|.||.:|||:.|:|..|.....||::|||:||.:||.||
Frog    61 IHKLLPELLQSTSFLTANGSLYIAFFCILRKLLGRFYFWTPGFGAALPASYAAILIERKSRRGLL 125

  Fly   130 TLYVANVATEALWKMAESRGWVRSVPNGQTLIFGVSMAALLYIYRTGTTKDSI----FNILRIFV 190
            |:|:||.|||||::|:.:||:::.:.:|:.|:|.::.|..::.:|   .:|.:    |:.|:..|
Frog   126 TIYMANQATEALFRMSVTRGYIKPIRHGEVLLFCITAALYMFFFR---CRDGLKGFAFSALKFIV 187

  Fly   191 GKEE--AGPIVKSGPAVPGEQPAPDRRRPTVSFSTVSDWVRVYSNLIR--AKHESCRH-QQSCIG 250
            ||||  |..:|........|:.....:| .:|.|::.   ::...:.:  .:|..|:| :.:||.
Frog   188 GKEEIPAHTLVPESMYARAEEKKSKEQR-GLSRSSIK---KLMDTICKHGPRHRCCKHYEDNCIS 248

  Fly   251 YSLMGGIKPFVGGVGLQVALKLVMNVKRITAGKMPWKKMIFNRGTLQLGIFMGSFSFLYKSVSCL 315
            |.:.|.|:.|..|..:|..|::....:.:.........:.:|:...|||.|:|||..:||..||.
Frog   249 YCVKGFIRMFSIGYLIQCCLRIPSTFRHLFTKPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCF 313

  Fly   316 LRHSFNRDDARFAIPASLIASISFTQYPDNTVALYVMWKALQILCTKGQEHGIVPHIPNFMLFLY 380
            ||...|.||...||.|..:|.||...|...|:::|:..|.::.:..||.|.|..|:.|:....:|
Frog   314 LRWVRNLDDELHAIVAGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKCPYFPHADSVIY 378

  Fly   381 SFFTAVLFHAGILEPKSLRPSYYKFLQAISGDRLSKFNLSAFDVFGLSSQQQALDTIKALN---I 442
            :..||:.|||.::|.::|||||:||||.::..|.:..|..|.|||...:.:...:.:..|:   .
Frog   379 AVSTAICFHAAVMEVQNLRPSYWKFLQRLTKGRFALMNRKALDVFDSEASKTFNNFVPKLDPRFC 443

  Fly   443 VEKSSLP 449
            |.|..||
Frog   444 VVKPELP 450

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11737	NP_001262370.1	TMEM135_C_rich	14..145	CDD:292604	49/131 (37%)
tmem135	XP_002936590.2	TMEM135_C_rich	9..142	CDD:374269	50/137 (36%)
tmem135	XP_002936590.2	Tim17	<295..347	CDD:367093	24/51 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	147	1.000	Domainoid score	I4467
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11295
Inparanoid	1	1.050	235	1.000	Inparanoid score	I3309
OMA	1	1.010	-	-		QHG49433
OrthoDB	1	1.010	-	-		D378483at33208
OrthoFinder	1	1.000	-	-		FOG0004145
OrthoInspector	1	1.000	-	-		otm48709
Panther	1	1.100	-	-	LDO	PTHR12459
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3968
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	12.080