DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ARSA and CG7402

DIOPT Version :9

Sequence 1:	XP_016884289.1	Gene:	ARSA / 410	HGNCID:	713	Length:	547	Species:	Homo sapiens
Sequence 2:	NP_649023.1	Gene:	CG7402 / 39994	FlyBaseID:	FBgn0036768	Length:	579	Species:	Drosophila melanogaster

Alignment Length:	570	Identity:	163/570 - (28%)
Similarity:	236/570 - (41%)	Gaps:	124/570 - (21%)

- Green bases have known domain annotations that are detailed below.

Human     8 SLLLALAAGLAVARPPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSLCT 72
            |.:|:||.|...:..||||:|..||:|..|:..:|.....|||:|.||..|:.....||| :|||
  Fly    13 SSILSLAYGSGYSTKPNIVIILIDDMGMNDVSFHGSNQILTPNIDALAYNGILLNKHYVP-NLCT 76

Human    73 PSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGAFL 137
            ||||.||||:.|:..||...|::.....|||..|..:.|:....||.|.:.||||||...:. ..
  Fly    77 PSRATLLTGKYPIHTGMQHFVIITDEPWGLPQRERLMPEIFRDAGYSTHLVGKWHLGFWRKD-LT 140

Human   138 PPHQGF-HRF----------------------LGIPYSHDQGPCQNLTCFPPATPCDGGCDQGLV 179
            |..:|| |.|                      .|:.:..|..||      |.|.
  Fly   141 PTMRGFDHHFGYYNGYIDYYDHQVRMLDRNYSAGLDFRRDLEPC------PEAN----------- 188

Human   180 PIPLLANLSVEAQPPWLPGLEARYMAFAHDLMADAQRQDRPFFLYYASH---HTHYPQFSGQSFA 241
                 ...:.||...     ||:.:...||       :.:|.|: ..||   ||.......|:..
  Fly   189 -----GTYATEAFTS-----EAKRIIEQHD-------KSKPLFM-VLSHLAVHTGNEDSPMQAPE 235

Human   242 ERSGRGP---------FGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRM-SRGGC 296
            |...:.|         :...:..||.:|...:.|:.|.|:|..::::..:|||..|:.: |..|.
  Fly   236 EEVAKFPHIRDPKRRTYAGMISSLDKSVAQTIGALKDNGMLNNSIILLYSDNGAPTIGIHSNAGS 300

Human   297 SGLLRCGKGTTYEGGVREPALAFWP------GHIAPGVTHELASSLDLLPTLAALAGAPLP-NVT 354
            :...|..|.:.:|||:|. |.|.|.      |:::....|    ::|.|||||..||..|| ::.
  Fly   301 NYPYRGQKESPWEGGIRS-AGALWSPLLKERGYVSNQAIH----AVDWLPTLAGAAGVSLPQDLP 360

Human   355 LDGFDLSPLLLGTGK-SPR------QSLFFYPSYPDEVRGVFAVRTGKYKAHFFTQGNPSPWIPP 412
            |||.:|.|:|.|..: .||      ..:|.|.||..:        |.||......:|....|:
  Fly   361 LDGINLWPMLSGNEEPKPRTMIHVLDEVFGYSSYMRD--------TLKYVNGSSFKGRYDQWL-- 415

Human   413 PDLLTPPRSP--RSLAPPLALALCTELAPSPG-------SAHSDTTAD-PACHASSSLTAH---E 464
            .:|.|....|  .|....:..:....|..:.|       ...|:.|.. |.....:.|.:|   |
  Fly   416 GELETNEDDPLGESYEQHVLASDVQSLLGNRGLTKDRIRQMRSEATETCPPIEGQNPLESHFKCE 480

Human   465 P---PLLYDLSKDPGENYNLLGGVAGATPEVLQAL--KQLQLLKAQLDAA 509
            |   |..:||:|||.|.|||    |...|..||.|  :..|:.|..:.:|
  Fly   481 PLKAPCFFDLAKDPCERYNL----AQMYPLQLQQLADELEQIRKTAIPSA 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ARSA	XP_016884289.1	None
CG7402	NP_649023.1	PRK13759	25..459	CDD:237491	133/485 (27%)
CG7402	NP_649023.1	4-S	28..436	CDD:293753	131/459 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157183
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG3119
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740