Protein Alignment ARSA and CG8646

DIOPT Version :10

• Sequence 1: NP_000478.3
• Gene: ARSA / 410
• HGNCID: 713
• Length: 509
• Species: Homo sapiens
• Sequence 2: NP_610807.3
• Gene: CG8646 / 36394
• FlyBaseID: FBgn0033763
• Length: 562
• Species: Drosophila melanogaster
• Alignment Length: 585
• Identity: 153/585 - (26%)
• Similarity: 231/585 - (39%)
• Gaps: 156/585 - (26%)

Human     9 LLLALAAGLAVAR---PPNIVLIFADDLGYGDLGCYGHPSSTTPNLDQLAAGGLRFTDFYVPVSL 70
            |||.:.....|.:   .|||:.|.|||||:.|:|.:|.....|||:|.||..|:....:|| ..:
  Fly     9 LLLPIIDAAEVEKSPAKPNIIFILADDLGFNDVGFHGSAEIPTPNIDALAYSGIILNRYYV-API 72

Human    71 CTPSRAALLTGRLPVRMGMYPGVLVPSSRGGLPLEEVTVAEVLAARGYLTGMAGKWHLGVGPEGA 135
            |||||:||:||:.|:..||...||..:...||||||..:.:.|...||.:.:|||||||.. :..
  Fly    73 CTPSRSALMTGKYPIHTGMQHTVLYAAEPRGLPLEEKILPQYLNELGYTSHIAGKWHLGHW-KLK 136

Human   136 FLPPHQGFHRFLGIPYSH----DQGPCQNLTCFPPATPCDGGCDQGLVPIPLLANLSVEAQPPWL 196
            :.|.::||...:|....|    |....:|         ...|.|        :.|
  Fly   137 YTPLYRGFSSHVGFWSGHQDYNDHTAVEN---------NQWGLD--------MRN---------- 174

Human   197 PGLEARYMAFAH-----------DLMADAQRQDRPFFLY--YASHH------------------T 230
             |.:..|....|           .::|:......|.|||  :|:.|                  :
  Fly   175 -GTQVAYDLHGHYTTDVITDHSVKVIANHNATKGPLFLYVAHAACHSSNPYNPLPVPDNDVIKMS 238

Human   231 HYPQFSGQSFAERSGRGPFGDSLMELDAAVGTLMTAIGDLGLLEETLVIFTADNGPETMRMSRGG 295
            |.|.:..:.||.         .:.::|.:||.::..:....:||.:::||::|||......:...
  Fly   239 HIPNYKRRKFAA---------MVSKMDNSVGQIVDQLRKSNMLENSIIIFSSDNGGPAQGFNLNF 294

Human   296 CSGL-LRCGKGTTYEGGVREPALAFWPGHI--APGVTHELASSLDLLPTLAALAGA--PLPNVT- 354
            .|.. |:..|.|.:|||||...| .|...:  :..|:::....:|.||||...||.  .|.|::
  Fly   295 ASNYPLKGVKNTLWEGGVRAAGL-MWSPLLKKSQRVSNQTMHIIDWLPTLLEAAGGQPALSNLSK 358

Human   355 -LDGFDLSPLLLGTGKSPRQSLFFYPSYPDEVRGVFAVRTGKYKAHFFT--QGS----------- 405
             :||..:...|:....|||.::.   ...|::.|..|:..|.:|....|  :||
  Fly   359 QIDGQSIWRALVQDKASPRLNVL---HNIDDIWGSAALSVGDWKLVKGTNYRGSWDGWYGPAGER 420

Human   406 --------------------------AHSD-----TTADPACHASSS------LTAHEPPLLYDL 433
                                      :.:|     ..|..:|...||      .||...|.|:.:
  Fly   421 DPRLYDWQLVGRSRAGKALEALKMLPSRADQQRIRAAATVSCPGQSSQGTSCVATAFSAPCLFHI 485

Human   434 SKDPGENYNLLGGVAGATPEVLQALKQLQLLKAQLDAAVTFGPSQVARGEDPALQICCHPGCTPR 498
            ..||.|.|||    |...|||:.|      |..:|:   .|..:.|.....||     .|...||
  Fly   486 RDDPCEQYNL----AKQYPEVVNA------LMTELE---RFNATAVPPSNKPA-----DPRADPR 532

Human   499  498
              Fly   533  532

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ARSA	NP_000478.3	ARSA	22..505	CDD:293777	149/569 (26%)
CG8646	NP_610807.3	4-S	26..405	CDD:293753	117/421 (28%)
		DUF4976	<480..510	CDD:419068	14/39 (36%)