Protein Alignment ASIC1 and ppk26

DIOPT Version :9

• Sequence 1: NP_064423.2
• Gene: ASIC1 / 41
• HGNCID: 100
• Length: 574
• Species: Homo sapiens
• Sequence 2: NP_648125.3
• Gene: ppk26 / 38835
• FlyBaseID: FBgn0035785
• Length: 597
• Species: Drosophila melanogaster
• Alignment Length: 624
• Identity: 126/624 - (20%)
• Similarity: 205/624 - (32%)
• Gaps: 194/624 - (31%)

Human     7 EEEV---------GGVQPVS--IQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCV 60
            |:||         .|.|...  |..:...:|:||:.::...:|..|:|..|....:  |:|..||
  Fly    49 EDEVDTKKQIKYGSGFQAAKAIIHEYCDYTTIHGIRYLGEKKRPLLERLFWISVLV--LSVFTCV 111

Human    61 -CTERVQYYFHYHHV-TKLDEVAAS--QLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNR 121
             .|..:...::.:.| ....|.:..  |:.|||||:|...:.|....:..|.||
  Fly   112 KLTLNIWDKWNNNPVIVSFAEKSTPVWQIPFPAVTVCPETKTRREIFNFTDSYH----------- 165

Human   122 YEIPDTQMADEKQLEILQDK------ANFRSFKPKPFNMREFYD-------RAGHDIRDML---- 169
             ::.|.| ::...:..|.||      |..:..:|      ..:|       |.|.:|.|.|
  Fly   166 -QVRDFQ-SNVSGIVDLSDKQKGLYGAVSQVCEP------HLHDVTLGNKTRRGMEIIDALTEVS 222

Human   170 -------LSCHFRGEVCSAED-FKVVFTRYGKCYTFNS--------------------------- 199
                   |:|.:|.......| |....|..|.|::|||
  Fly   223 PHFDDTYLNCKWRNSPVKCSDIFHKFVTEDGVCFSFNSLSPAEIFRAEGIIPDFIFREENRLSMD 287

Human   200 ---------GRDGRPRLKTMKG-GTGNGLEIML---DIQQDEYL--PVWGETDETSFEAGIKVQI 249
                     ..|..|....:.| |...||.:.:   :|..|:..  ||          .|.|:.:
  Fly   288 WNVEDGYSASADTSPYPNRVLGPGARAGLYLFMGGAEIDFDDMCRGPV----------QGFKILL 342

Human   250 HSQDEP----------PFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDS 304
            |:..:.          ||..::...:.|...|    ....|.:..|....| ....:.:|.:|:.
  Fly   343 HTPGDVAQVSKQYFRIPFDQEVLISIRPKIIT----TSDGLKHYEPNRRQC-YFQKERELRYFNI 402

Human   305 YSITACRIDCETRYLVENCNCRMVHMPGDA--PYCTPEQYKECADPALDFLVEKD---------- 357
            ||.:.|.::|...:.:..|.|....||.:.  |.|.....| |.:.|.|.|:.::
  Fly   403 YSQSNCELECLANFTLTKCGCVKFSMPRNVNMPVCGDASLK-CYNQAEDELLLREFTQGLVNAGE 466

Human   358 ----QEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQ--YIGENILVLDIFFEVLN 416
                :..|.|...|....|..|:|......|......:.: .|.||  ..|..:..:.|||:...
  Fly   467 NTRGETECNCLPSCTSIAYEAEISQADFDYKTVINTDSPE-GKEEQSKRQGMKMSRVSIFFKEAQ 530

Human   417 YETIEQKKAYEIAGLLGELLMTPVPFSCHGHGVAPYHPKAGCSLLSHEGPPPQRPFPKPCCLGDI 481
            :.|..:.:.|.....|                       |.|
  Fly   531 FLTSRRSELYGTTDFL-----------------------ANC----------------------- 549

Human   482 GGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKE 520
            ||.:|||:|.|:|:::||..:....:...|..|.|.:||
  Fly   550 GGLLGLFMGVSMLSIVELIYFCTVRLISNLRMRRKTRKE 588

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ASIC1	NP_064423.2	ENaC	19..556	CDD:273304	120/601 (20%)
ppk26	NP_648125.3	ASC	74..570	CDD:279230	115/579 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7068
eggNOG	1	0.900	-	-		E1_KOG4294
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	101	1.000	Inparanoid score	I4987
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D303969at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11690
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X60
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.970