DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stck and LIMD1

DIOPT Version :9

Sequence 1:	NP_731242.1	Gene:	stck / 40999	FlyBaseID:	FBgn0020249	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	NP_055055.1	Gene:	LIMD1 / 8994	HGNCID:	6612	Length:	676	Species:	Homo sapiens

Alignment Length:	293	Identity:	73/293 - (24%)
Similarity:	108/293 - (36%)	Gaps:	104/293 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CTRCADGFEPTEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRKYCERDFHVLF------A 79
            |.:|:.|.....:...:.|.|:|..||.||.|.|..:...||...|:.:||.||  |:      |
Human   472 CVKCSKGVFGAGQACQAMGNLYHDTCFTCAACSRKLRGKAFYFVNGKVFCEEDF--LYSGFQQSA 534

  Fly    80 PCCNKCGEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECNAKVKAEITGRY 144
            ..|..||..::..:::|:..|:||.||||                  .:|:||
Human   535 DRCFLCGHLIMDMILQALGKSYHPGCFRC------------------VICNEC------------ 569

  Fly   145 VCQKCHGLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSRPGLAANDMNELYCLRCHDKM 209
                                              ||.....|.|.        |::||:|.:.|:
Human   570 ----------------------------------LDGVPFTVDSE--------NKIYCVRDYHKV 592

  Fly   210 GIPICGACRRPI------EERV-VTALGKHWHVEHFVCAKCEKPFL---GHRHYEKRGLAYCETH 264
            ..|.|.||..||      :|.: |.::.:.:|||.:.|..|.....   |||.|.      .|.|
Human   593 LAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYP------LEDH 651

  Fly   265 YHQLFGNLCFVCNQVIGGDVFTALNKAWCVHHF 297
               ||.:.|.| .::......|||::    |||
Human   652 ---LFCHSCHV-KRLEKRPSSTALHQ----HHF 676

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stck	NP_731242.1	LIM1_PINCH	21..79	CDD:188717	20/63 (32%)
		LIM2_PINCH	82..133	CDD:188718	13/50 (26%)
		LIM3_PINCH	146..206	CDD:188719	8/59 (14%)
		LIM4_PINCH	212..265	CDD:188720	18/62 (29%)
		LIM5_PINCH	273..326	CDD:188721	8/25 (32%)
LIMD1	NP_055055.1	Mediates nuclear export	54..134
		Atrophin-1	<69..443	CDD:331285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..163
		Interaction with EGLN1/PHD2	186..260
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..389
		Interaction with RB1. /evidence=ECO:0000269\|PubMed:15542589	404..442
		Necessary for nuclear localization	472..676		71/291 (24%)
		LIM1_Ajuba_like	472..525	CDD:188738	17/52 (33%)
		LIM2_Ajuba_like	537..589	CDD:188741	22/123 (18%)
		LIM3_Ajuba_like	597..658	CDD:188822	20/69 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900