DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stck and TRIP6

DIOPT Version :9

Sequence 1:	NP_731242.1	Gene:	stck / 40999	FlyBaseID:	FBgn0020249	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	NP_003293.2	Gene:	TRIP6 / 7205	HGNCID:	12311	Length:	476	Species:	Homo sapiens

Alignment Length:	188	Identity:	49/188 - (26%)
Similarity:	73/188 - (38%)	Gaps:	37/188 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LWHTQCFVCAQCFRPFQDGIFYEFEGRKYCERDFHVLFAPCCNKCGEFVIGRVIKAMSASWHPQC 105
            ::|..||||:.|....:...||..|.|.||| ..:|.....|..|.:.::.|:::||..::||.|
Human   299 VFHVGCFVCSTCRAQLRGQHFYAVERRAYCE-GCYVATLEKCATCSQPILDRILRAMGKAYHPGC 362

  Fly   106 FRCQLCAKELADCGFIKNQNRALCHECNAKVKAEITGRYVCQKCHGLIDEEPLRFRGE------- 163
            |.|.:|.:.|....|..:....:  .|......:...|  |..|.|.|..||    |:
Human   363 FTCVVCHRGLDGIPFTVDATSQI--HCIEDFHRKFAPR--CSVCGGAIMPEP----GQEETVRIV 419

  Fly   164 -VYHGYH---FSCTACGTELDSTAREVKSRPGLAANDMNELYCLRCHDKMGIPICGAC 217
             :...:|   :.|..||..|.|                 |..|..|:...|..:|.||
Human   420 ALDRSFHIGCYKCEECGLLLSS-----------------EGECQGCYPLDGHILCKAC 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stck	NP_731242.1	LIM1_PINCH	21..79	CDD:188717	14/37 (38%)
		LIM2_PINCH	82..133	CDD:188718	13/50 (26%)
		LIM3_PINCH	146..206	CDD:188719	15/70 (21%)
		LIM4_PINCH	212..265	CDD:188720	3/6 (50%)
		LIM5_PINCH	273..326	CDD:188721
TRIP6	NP_003293.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..93
		Atrophin-1	<8..251	CDD:331285
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	108..253
		LIM1_TRIP6	279..332	CDD:188736	13/33 (39%)
		LIM	339..398	CDD:295319	14/60 (23%)
		LIM3_Zyxin_like	399..461	CDD:188743	20/83 (24%)
		Interaction with MAGI1 and PTPN13. /evidence=ECO:0000269\|PubMed:19017743	469..476
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810