DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stck and PXN

DIOPT Version :9

Sequence 1:	NP_731242.1	Gene:	stck / 40999	FlyBaseID:	FBgn0020249	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	XP_016875215.1	Gene:	PXN / 5829	HGNCID:	9718	Length:	1135	Species:	Homo sapiens

Alignment Length:	322	Identity:	95/322 - (29%)
Similarity:	133/322 - (41%)	Gaps:	81/322 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SKAEVVQAANMSLGAMHCTRCADGFEPTEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRK 68
            :|..|...|....||  |.:...|     ::|.:.|:.||.:.|||..|........|:|.:|:.
Human   890 NKLGVATVAKGVCGA--CKKPIAG-----QVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQP 947

  Fly    69 YCERDFHVLFAPCCNKCGEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECN 133
            |||:|:|.||:|.|..|...::.:|:.|:..:|||:.|.|       |.||
Human   948 YCEKDYHNLFSPRCYYCNGPILDKVVTALDRTWHPEHFFC-------AQCG-------------- 991

  Fly   134 AKVKAEITGRYVCQKCHGLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSRPGLAANDMN 198
                                     .|.|.  .|:|        |.|..|
Human   992 -------------------------AFFGP--EGFH--------EKDGKA--------------- 1006

  Fly   199 ELYCLRCHDKMGIPICGACRRPIEERVVTALGKHWHVEHFVCAKCEKPFLGHRHYEKRGLAYCET 263
              ||.:.:..|..|.||.|.|.|.|..::||...||.|.|||.:|..||:....:|..|..|||.
Human  1007 --YCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEV 1069

  Fly   264 HYHQLFGNLCFVCNQVIGGDVFTALNKAWCVHHFACSVCDTKMTQKSKFYEYDEKPVCKKCY 325
            |||:..|:||..|.:.|.|...||:.|.:...||.|:.| .|...|..|.|.::||.|:.|:
Human  1070 HYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFC-LKQLNKGTFKEQNDKPYCQNCF 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stck	NP_731242.1	LIM1_PINCH	21..79	CDD:188717	19/57 (33%)
		LIM2_PINCH	82..133	CDD:188718	12/50 (24%)
		LIM3_PINCH	146..206	CDD:188719	9/59 (15%)
		LIM4_PINCH	212..265	CDD:188720	23/52 (44%)
		LIM5_PINCH	273..326	CDD:188721	19/53 (36%)
PXN	XP_016875215.1	Paxillin	60..259	CDD:281527
		LIM1_Paxillin_like	902..954	CDD:259830	19/58 (33%)
		LIM2_Paxillin	961..1012	CDD:188791	21/123 (17%)
		LIM3_Paxillin_like	1020..1072	CDD:188724	23/51 (45%)
		LIM4_Paxillin	1079..1130	CDD:188795	18/51 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.920