DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stck and Limd1

DIOPT Version :9

Sequence 1:	NP_731242.1	Gene:	stck / 40999	FlyBaseID:	FBgn0020249	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	NP_001106208.1	Gene:	Limd1 / 316101	RGDID:	1309830	Length:	663	Species:	Rattus norvegicus

Alignment Length:	293	Identity:	72/293 - (24%)
Similarity:	109/293 - (37%)	Gaps:	104/293 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CTRCADGFEPTEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRKYCERDFHVLF------A 79
            |.:|:.|.....:...:.|:|:|..||.||.|.|..:...||...|:.:||.||  |:      |
  Rat   459 CVKCSKGVFGAGQACQAMGDLYHDACFTCAACSRKLRGKAFYFVNGKVFCEEDF--LYSGFQQSA 521

  Fly    80 PCCNKCGEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECNAKVKAEITGRY 144
            ..|..||..::..:::|:..|:||.||||                  .:|:||
  Rat   522 DRCFLCGHLIMDMILQALGKSYHPGCFRC------------------VICNEC------------ 556

  Fly   145 VCQKCHGLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSRPGLAANDMNELYCLRCHDKM 209
                                              ||.....|.|.        |::||:|.:.|:
  Rat   557 ----------------------------------LDGVPFTVDSE--------NKIYCVRDYHKV 579

  Fly   210 GIPICGACRRPI------EERV-VTALGKHWHVEHFVCAKCEKPFL---GHRHYEKRGLAYCETH 264
            ..|.|.||..||      :|.: |.::.:.:|||.:.|..|.....   |||.|.      .|.|
  Rat   580 LAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYP------LEDH 638

  Fly   265 YHQLFGNLCFVCNQVIGGDVFTALNKAWCVHHF 297
               ||.:.|.| .::..|....:|::    |||
  Rat   639 ---LFCHSCHV-KRLEKGPSPASLHQ----HHF 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stck	NP_731242.1	LIM1_PINCH	21..79	CDD:188717	20/63 (32%)
		LIM2_PINCH	82..133	CDD:188718	13/50 (26%)
		LIM3_PINCH	146..206	CDD:188719	8/59 (14%)
		LIM4_PINCH	212..265	CDD:188720	18/62 (29%)
		LIM5_PINCH	273..326	CDD:188721	7/25 (28%)
Limd1	NP_001106208.1	Mediates nuclear export. /evidence=ECO:0000250	54..128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..99
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	117..158
		Interaction with EGLN1/PHD2. /evidence=ECO:0000250	180..251
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	230..253
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	267..297
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..416
		Interaction with RB1. /evidence=ECO:0000250	391..429
		Necessary for nuclear localization. /evidence=ECO:0000250	459..663		70/291 (24%)
		LIM1_Ajuba_like	459..512	CDD:188738	17/52 (33%)
		LIM2_Ajuba_like	524..576	CDD:188741	22/123 (18%)
		LIM3_Ajuba_like	584..645	CDD:188822	20/69 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900