DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stck and Limd1

DIOPT Version :9

Sequence 1:	NP_731242.1	Gene:	stck / 40999	FlyBaseID:	FBgn0020249	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	NP_038888.2	Gene:	Limd1 / 29806	MGIID:	1352502	Length:	668	Species:	Mus musculus

Alignment Length:	265	Identity:	64/265 - (24%)
Similarity:	98/265 - (36%)	Gaps:	91/265 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CTRCADGFEPTEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRKYCERDFHVLF------A 79
            |.:|:.|.....:...:.|:|:|..||.||.|.|..:...||...|:.:||.||  |:      |
Mouse   464 CVKCSKGVFGAGQACQAMGDLYHDACFTCAACSRKLRGKAFYFVNGKVFCEEDF--LYSGFQQSA 526

  Fly    80 PCCNKCGEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECNAKVKAEITGRY 144
            ..|..||..::..:::|:..|:||.||||                  .:|:||
Mouse   527 DRCFLCGHLIMDMILQALGKSYHPGCFRC------------------VICNEC------------ 561

  Fly   145 VCQKCHGLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSRPGLAANDMNELYCLRCHDKM 209
                                              ||.....|.|.        |::||:|.:.|:
Mouse   562 ----------------------------------LDGVPFTVDSE--------NKIYCVRDYHKV 584

  Fly   210 GIPICGACRRPI------EERV-VTALGKHWHVEHFVCAKCEKPFL---GHRHYEKRGLAYCET- 263
            ..|.|.||..||      :|.: |.::.:.:|||.:.|..|.....   |||.|......:|.:
Mouse   585 LAPKCAACGLPILPPEGSDETIRVVSMDRDYHVECYHCEDCGLELNDEDGHRCYPLEDHLFCHSC 649

  Fly   264 HYHQL 268
            |..:|
Mouse   650 HVKRL 654

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stck	NP_731242.1	LIM1_PINCH	21..79	CDD:188717	20/63 (32%)
		LIM2_PINCH	82..133	CDD:188718	13/50 (26%)
		LIM3_PINCH	146..206	CDD:188719	8/59 (14%)
		LIM4_PINCH	212..265	CDD:188720	18/63 (29%)
		LIM5_PINCH	273..326	CDD:188721
Limd1	NP_038888.2	Mediates nuclear export. /evidence=ECO:0000250	54..128
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	74..160
		Interaction with EGLN1/PHD2. /evidence=ECO:0000250	181..256
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	239..258
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	277..309
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	340..414
		Interaction with RB1. /evidence=ECO:0000250	396..434
		Necessary for nuclear localization. /evidence=ECO:0000250	464..668		64/265 (24%)
		LIM1_Ajuba_like	464..517	CDD:188738	17/52 (33%)
		LIM2_Ajuba_like	529..581	CDD:188741	22/123 (18%)
		LIM3_Ajuba_like	589..650	CDD:188822	17/60 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1704
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900