DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment stck and Pxn

DIOPT Version :9

Sequence 1:NP_731242.1 Gene:stck / 40999 FlyBaseID:FBgn0020249 Length:348 Species:Drosophila melanogaster
Sequence 2:XP_006530265.1 Gene:Pxn / 19303 MGIID:108295 Length:1088 Species:Mus musculus


Alignment Length:322 Identity:95/322 - (29%)
Similarity:133/322 - (41%) Gaps:81/322 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 SKAEVVQAANMSLGAMHCTRCADGFEPTEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRK 68
            :|..|...|....||  |.:...|     ::|.:.|:.||.:.|||..|........|:|.:|:.
Mouse   843 NKLGVATVAKGVCGA--CKKPIAG-----QVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQP 900

  Fly    69 YCERDFHVLFAPCCNKCGEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECN 133
            |||:|:|.||:|.|..|...::.:|:.|:..:|||:.|.|       |.||              
Mouse   901 YCEKDYHSLFSPRCYYCNGPILDKVVTALDRTWHPEHFFC-------AQCG-------------- 944

  Fly   134 AKVKAEITGRYVCQKCHGLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSRPGLAANDMN 198
                                     .|.|.  .|:|        |.|..|               
Mouse   945 -------------------------AFFGP--EGFH--------EKDGKA--------------- 959

  Fly   199 ELYCLRCHDKMGIPICGACRRPIEERVVTALGKHWHVEHFVCAKCEKPFLGHRHYEKRGLAYCET 263
              ||.:.:..|..|.||.|.|.|.|..::||...||.|.|||.:|..||:....:|..|..|||.
Mouse   960 --YCRKDYFDMFAPKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEV 1022

  Fly   264 HYHQLFGNLCFVCNQVIGGDVFTALNKAWCVHHFACSVCDTKMTQKSKFYEYDEKPVCKKCY 325
            |||:..|:||..|.:.|.|...||:.|.:...||.|:.| .|...|..|.|.::||.|:.|:
Mouse  1023 HYHERRGSLCSGCQKPITGRCITAMAKKFHPEHFVCAFC-LKQLNKGTFKEQNDKPYCQSCF 1083

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stckNP_731242.1 LIM1_PINCH 21..79 CDD:188717 19/57 (33%)
LIM2_PINCH 82..133 CDD:188718 12/50 (24%)
LIM3_PINCH 146..206 CDD:188719 9/59 (15%)
LIM4_PINCH 212..265 CDD:188720 23/52 (44%)
LIM5_PINCH 273..326 CDD:188721 19/53 (36%)
PxnXP_006530265.1 Paxillin 54..253 CDD:367550
LIM1_Paxillin_like 855..907 CDD:259830 19/58 (33%)
LIM2_Paxillin 914..965 CDD:188791 21/123 (17%)
LIM3_Paxillin_like 973..1025 CDD:188724 23/51 (45%)
LIM4_Paxillin 1032..1083 CDD:188795 18/51 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1593918at2759
OrthoFinder 1 1.000 - - FOG0000055
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X39
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.920

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