DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment stck and prkl-1

DIOPT Version :9

Sequence 1:	NP_731242.1	Gene:	stck / 40999	FlyBaseID:	FBgn0020249	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	NP_741435.2	Gene:	prkl-1 / 177463	WormBaseID:	WBGene00022727	Length:	523	Species:	Caenorhabditis elegans

Alignment Length:	357	Identity:	89/357 - (24%)
Similarity:	131/357 - (36%)	Gaps:	90/357 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 PTEKI--VNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRKYCE----------RDFH------- 75
            |..|:  :.|.||.|..:   .::...|.||      ...:|||          |.|.
Worm    79 PENKVPFIGSAGEKWRQR---QSRYQLPPQD------SDVRYCEDLNAEEADTLRMFERTRKTEC 134

  Fly    76 -----VLFAPC---CNKCGEFVIGRVIKAMSA----SWHPQCFRCQLCAKELADCGFIKNQNRAL 128
                 |.:||.   |.||.:.:....|..|:|    .:||.|||||.|...|.|..:..:.|:..
Worm   135 LGSGVVQYAPFDTKCEKCPKRLEEGEISVMAARTGKRYHPSCFRCQTCDVLLVDLIYFAHDNQIY 199

  Fly   129 CHECNAKVKAEITGRYVCQKCHGLI-DEEPLRFRGEVYHGYHFSCTACGTEL-DSTAREVKSRPG 191
            |...:|:   ::..|  |.||..:| .:|.|...|..:|.:||.|..|...| |....:..::|
Worm   200 CGRHHAE---QVKPR--CAKCDEVIFGDECLEAEGRSWHFHHFQCAQCNDVLADQKYMQRANKP- 258

  Fly   192 LAANDMNELYCLRC-HDKMGIPICGACRRPIEERV--VTALGKHWH--VEHFVCAKCEKPFLGHR 251
                     .||:| |.......|..||.......  ::....|||  .|.|.|..|.|..||.:
Worm   259 ---------VCLKCFHSSSSTFSCTTCRLSFSSDTPHMSQGDLHWHASAECFCCCVCSKNLLGVK 314

  Fly   252 HYEKRGLAYCETHYHQLFGNLCFVCNQVIGGDVFTAL--NKAWCVHHFACSVCDTKMTQKSKFYE 314
                          :...|...|...|..||:....|  ::....|.        |:||||.  :
Worm   315 --------------YSRVGESLFCGYQTCGGEDEELLDEDRLGSPHR--------KVTQKST--K 355

  Fly   315 YDEKPVCKKCYDRFPNELRRRLRTAHEMTMKK 346
            ....|...:...|.|:.:::.|.|.  ||::|
Worm   356 VVRIPASPRVAPRHPHVIQQNLTTT--MTIQK 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stck	NP_731242.1	LIM1_PINCH	21..79	CDD:188717	15/72 (21%)
		LIM2_PINCH	82..133	CDD:188718	18/54 (33%)
		LIM3_PINCH	146..206	CDD:188719	18/62 (29%)
		LIM4_PINCH	212..265	CDD:188720	13/56 (23%)
		LIM5_PINCH	273..326	CDD:188721	12/54 (22%)
prkl-1	NP_741435.2	PET_Prickle	48..144	CDD:193602	15/73 (21%)
		LIM1_Testin_like	149..204	CDD:188726	18/54 (33%)
		LIM2_Testin_like	210..262	CDD:188727	17/63 (27%)
		LIM	283..324	CDD:295319	11/54 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910