DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment stck and PRICKLE2

DIOPT Version :9

Sequence 1:NP_731242.1 Gene:stck / 40999 FlyBaseID:FBgn0020249 Length:348 Species:Drosophila melanogaster
Sequence 2:XP_011531734.1 Gene:PRICKLE2 / 166336 HGNCID:20340 Length:966 Species:Homo sapiens


Alignment Length:282 Identity:72/282 - (25%)
Similarity:101/282 - (35%) Gaps:82/282 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 PTEKI--VNSNGE------LWHTQCFVCAQCFRPFQDGIFYEFEGRKYCE--------------- 71
            |.||:  |||.||      |.|.        ..|..:.:       :||.               
Human   149 PEEKVPYVNSPGEKLRIKQLLHQ--------LPPHDNEV-------RYCNSLDEEEKRELKLFSS 198

  Fly    72 ------------RDFHV-LFAPCCNKCGEFVIGRVIKAMSAS-------WHPQCFRCQLCAKELA 116
                        |.|.| :....|.:||..:.|..| |:.||       |||.||.|.:|.:.|.
Human   199 QRKRENLGRGNVRPFPVTMTGAICEQCGGQINGGDI-AVFASRAGHGVCWHPPCFVCTVCNELLV 262

  Fly   117 DCGFIKNQNRALCHECNAK-VKAEITGRYVCQKCHGLI-DEEPLRFRGEVYHGYHFSCTACGTEL 179
            |..:.....:..|...:|: :|..      |..|..:| .:|.....|..:|..||.|..|.|.|
Human   263 DLIYFYQDGKIYCGRHHAECLKPR------CAACDEIIFADECTEAEGRHWHMKHFCCFECETVL 321

  Fly   180 DSTAREVK-SRPGLAANDMNELYCLRCHDKMGIPICGACRR--PIEERVVTALGKHWHVEH--FV 239
            ......:| .||          ||..|.:.:....|..|.:  .|::..:|..|:|||...  |.
Human   322 GGQRYIMKEGRP----------YCCHCFESLYAEYCDTCAQHIGIDQGQMTYDGQHWHATETCFC 376

  Fly   240 CAKCEKPFLGHRHYEKRGLAYC 261
            ||.|:|..||.....|:|..:|
Human   377 CAHCKKSLLGRPFLPKQGQIFC 398

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
stckNP_731242.1 LIM1_PINCH 21..79 CDD:188717 16/84 (19%)
LIM2_PINCH 82..133 CDD:188718 18/57 (32%)
LIM3_PINCH 146..206 CDD:188719 17/61 (28%)
LIM4_PINCH 212..265 CDD:188720 18/54 (33%)
LIM5_PINCH 273..326 CDD:188721
PRICKLE2XP_011531734.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1704
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X39
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.810

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