DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment stck and tgfb1i1

DIOPT Version :9

Sequence 1:	NP_731242.1	Gene:	stck / 40999	FlyBaseID:	FBgn0020249	Length:	348	Species:	Drosophila melanogaster
Sequence 2:	XP_012825390.2	Gene:	tgfb1i1 / 100038241	XenbaseID:	XB-GENE-493249	Length:	503	Species:	Xenopus tropicalis

Alignment Length:	307	Identity:	86/307 - (28%)
Similarity:	126/307 - (41%)	Gaps:	79/307 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 CTRCADGFEPTEKIVNSNGELWHTQCFVCAQCFRPFQDGIFYEFEGRKYCERDFHVLFAPCCNKC 85
            |.|...|     ::|.:.|..||.:.||||.|........|:|.:||.|||:|:.:|:||.|..|
Frog   273 CQRPIAG-----QVVTALGHTWHPEHFVCAHCHALIGTTNFFEKDGRPYCEKDYFMLYAPRCALC 332

  Fly    86 GEFVIGRVIKAMSASWHPQCFRCQLCAKELADCGFIKNQNRALCHECNAKVKAEITGRYVCQKCH 150
            ...::..::.|:..:|||:.|.|::|.|.:.:.||         ||.:
Frog   333 ELPIVQNMVTALGCTWHPEHFCCKVCKKPIGEEGF---------HEKD----------------- 371

  Fly   151 GLIDEEPLRFRGEVYHGYHFSCTACGTELDSTAREVKSRPGLAANDMNELYCLRCHDKMGIPICG 215
                                                           .|.||...:.::...:|.
Frog   372 -----------------------------------------------GEQYCSDDYFRLFGAVCA 389

  Fly   216 ACRRPIEERVVTALGKHWHVEHFVCAKCEKPFLGHRHYEKRGLAYCETHYHQLFGNLCFVCNQVI 280
            .|...::|..::|||..||.:.|||..|..||:....:|..||..||||||...|:||..|.|.|
Frog   390 GCSEAVKESYISALGGLWHPQCFVCHVCHTPFINGSFFEHEGLPLCETHYHSRRGSLCAGCEQPI 454

  Fly   281 GGDVFTALNKAWCVHHFACSVCDTKMTQKSKFYEYDEKPVCKKCYDR 327
            .|...||:.|.:...|..|:.| .:...|..|.|:|.||.|:.||.|
Frog   455 TGRCVTAMGKKFHPQHLNCTFC-LRQLNKGTFREHDGKPYCQACYAR 500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
stck	NP_731242.1	LIM1_PINCH	21..79	CDD:188717	21/57 (37%)
		LIM2_PINCH	82..133	CDD:188718	14/50 (28%)
		LIM3_PINCH	146..206	CDD:188719	3/59 (5%)
		LIM4_PINCH	212..265	CDD:188720	20/52 (38%)
		LIM5_PINCH	273..326	CDD:188721	19/52 (37%)
tgfb1i1	XP_012825390.2	Paxillin	<61..>117	CDD:397550
		LIM1_Paxillin_like	270..322	CDD:259830	20/53 (38%)
		LIM2_Paxillin_like	329..380	CDD:188723	17/123 (14%)
		LIM3_Paxillin_like	388..440	CDD:188724	21/51 (41%)
		LIM4_Paxillin_like	447..498	CDD:188725	18/51 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1593918at2759
OrthoFinder	1	1.000	-	-		FOG0000055
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X39
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010