Protein Alignment Atg13 and ATG13

DIOPT Version :9

• Sequence 1: NP_649796.1
• Gene: Atg13 / 40998
• FlyBaseID: FBgn0261108
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_001192048.1
• Gene: ATG13 / 9776
• HGNCID: 29091
• Length: 550
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 164/605 - (27%)
• Similarity: 255/605 - (42%)
• Gaps: 173/605 - (28%)

  Fly     6 LNAAER-DLEKFIKFLVLKSTQVVVQSRLGEKMQTQCNPL-AGSDWFNIAVQDHPEVLDETKRAL 68
            ||:.:| ||:|||||..||:.||:||:|||||:.|:.:.. .||||||:|::|.|||..|.|:||
Human     5 LNSQDRKDLDKFIKFFALKTVQVIVQARLGEKICTRSSSSPTGSDWFNLAIKDIPEVTHEAKKAL 69

  Fly    69 NLKTGESILQRLPLCVEISLKTTEGDQMVLEVWSLDLLQPQNGASPATNDLNPEGQTLKAAHAIY 133
               .|:.......:||||||||:|||.|.||:|.|::.:..:             :.:|.::.:|
Human    70 ---AGQLPAVGRSMCVEISLKTSEGDSMELEIWCLEMNEKCD-------------KEIKVSYTVY 118

  Fly   134 NRMGIMLKSLISLTRTTPAYKLSRRQCPDSYGIFYRIYVDRPQVHTLGEGHKHVKIGQLSTIVGS 198
            ||:.::||||:::||.||||:|||:| ...|.|.||||....|:..||||.:.|::|.:.|.||:
Human   119 NRLSLLLKSLLAITRVTPAYRLSRKQ-GHEYVILYRIYFGEVQLSGLGEGFQTVRVGTVGTPVGT 182

  Fly   199 LVMSVAYRTKLTISPTAAQSESNTIM-LKSDHF----RPATDANTPGNQQQTQNGTVVAKKLGLG 258
            :.:|.|||..|....|.....:..|| :..|||    .|::....|.|.:.....|        |
Human   183 ITLSCAYRINLAFMSTRQFERTPPIMGIIIDHFVDRPYPSSSPMHPCNYRTAGEDT--------G 239

  Fly   259 ALNP----AQGTADRRFI-------------------------DIEKPLRPGAFTDMGKLKQYT- 293
            .:.|    :|......|.                         .:..|:...||:......:.:
Human   240 VIYPSVEDSQEVCTTSFSTSPPSQCVFTVTKAHFQTPTPVVTDTLRVPMAGLAFSHQLSSSRLSY 304

  Fly   294 --------EDDFVLP--------ETPPFEWLLRGR-GSVESL-------NRLDNNSVASVNISNN 334
                    ..|...|        .|.|.:.::.|: |.|...       .:.|...:|:...|:.
Human   305 QPAALGVGSADLAYPVVFAAGLNATHPHQLMVPGKEGGVPLAPNQPVHGTQADQERLATCTPSDR 369

  Fly   335 N------NSTQDSKFNQISNLNNNSAGFKS---------------FEKNSENSVSPIKSLLIPAS 378
            .      :|::|::     .::|:|.|..|               |.....|.|: :.||.||.:
Human   370 THCAATPSSSEDTE-----TVSNSSEGRASPHDVLETIFVRKVGAFVNKPINQVT-LTSLDIPFA 428

  Fly   379 ATATYR---HHSEPSLQPP--PDDDNLLK-ELHFPFASPTSHVN--------------------- 416
            ..|...   ..::|.:.||  |:.::.|: .||...:|..|..|
Human   429 MFAPKNLELEDTDPMVNPPDSPETESPLQGSLHSDGSSGGSSGNTHDDFVMIDFKPAFSKDDILP 493

  Fly   417 -DLAKFYRECYHAPPLKGLNELQAEISSISSTPPASSGSGGVAACGPTAAATAIATSSADASAMD 480
             ||..|||| :..||         ::||:|....|.|                      .|..:|
Human   494 MDLGTFYRE-FQNPP---------QLSSLSIDIGAQS----------------------MAEDLD 526

  Fly   481 DLSRQLEQFETSLEDYDKLV 500
            .|..:|...|.::.::|..|
Human   527 SLPEKLAVHEKNVREFDAFV 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atg13	NP_649796.1	ATG13	22..207	CDD:287051	81/185 (44%)
ATG13	NP_001192048.1	ATG13	19..195	CDD:287051	84/192 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159031
Domainoid	1	1.000	90	1.000	Domainoid score	I7797
eggNOG	1	0.900	-	-		E1_KOG3874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395102at33208
OrthoFinder	1	1.000	-	-		FOG0004173
OrthoInspector	1	1.000	-	-		oto90327
orthoMCL	1	0.900	-	-		OOG6_107732
Panther	1	1.100	-	-	LDO	PTHR13430
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2414
SonicParanoid	1	1.000	-	-		X5992
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.740