DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atg13 and atg13

DIOPT Version :9

Sequence 1:	NP_649796.1	Gene:	Atg13 / 40998	FlyBaseID:	FBgn0261108	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_005169027.1	Gene:	atg13 / 393405	ZFINID:	ZDB-GENE-040426-1149	Length:	536	Species:	Danio rerio

Alignment Length:	588	Identity:	161/588 - (27%)
Similarity:	249/588 - (42%)	Gaps:	162/588 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 ERDLEKFIKFLVLKSTQVVVQSRLGEKMQTQCNPLA--GSDWFNIAVQDHPEVLDETKRALNLKT 72
            ::||:|||||..||:.||:||:|||||:.| |:..:  ||||||:|::|.|||..|.|:||   .
Zfish    10 KKDLDKFIKFFALKTVQVIVQARLGEKIST-CSSSSPTGSDWFNLAIKDIPEVTHEAKKAL---A 70

  Fly    73 GESILQRLP-----LCVEISLKTTEGDQMVLEVWSLDLLQPQNGASPATNDLNPEGQTLKAAHAI 132
            |:     ||     :||||||||:|||.|.||.|.|::.:..:             :.:|.::.:
Zfish    71 GQ-----LPGIGRSMCVEISLKTSEGDSMELETWCLEMNEKCD-------------KDIKVSYTV 117

  Fly   133 YNRMGIMLKSLISLTRTTPAYKLSRRQCPDSYGIFYRIYVDRPQVHTLGEGHKHVKIGQLSTIVG 197
            |||:.::||||:::||.||||||||:|..| |.|.||||....|:..||||.:.|::|.:.|.:|
Zfish   118 YNRLSLLLKSLLAITRVTPAYKLSRQQGHD-YVILYRIYFGDVQLTGLGEGFQTVRVGIVGTPIG 181

  Fly   198 SLVMSVAYRTKLTISPTAAQSESNTIM-LKSDHF--RPAT----------------DANTPGNQQ 243
            ::.:|.||||.|.:..:.....:..|| :..|||  ||.|                |..|....:
Zfish   182 TITLSCAYRTNLALVSSRQFERTGPIMGIIIDHFVERPFTNMAHTHPCSYRAPGEDDGGTYAGIE 246

  Fly   244 QTQN-------------------------------GTVVAKKLGLGA-----------LNPAQGT 266
            .:|.                               .|:....:|||.           ..|..||
Zfish   247 DSQEVCTTSFSTSPPSQCVCTVSQAHFKTPKPALMATLKVPLMGLGISQQLYSSRLSYQTPPLGT 311

  Fly   267 AD-------------RRFIDIEK-------PLRP--GAFTDMGKLKQYTEDDFVLPETPPFEWLL 309
            .|             .:.:...|       |.:|  |...:.|::.......  .|:.||.....
Zfish   312 VDLCHPTACTGAAHPHQMVVPGKDGGIPQVPAQPNHGTGAEQGRIPSCPTGQ--PPQLPPPTSCS 374

  Fly   310 RGRGSVESLNRLDNNSVASVNISNNNNSTQDSKFNQISNLNNNSAGF--KSFEKNSENSV----- 367
            ....:|...:.|:......|....|..:||.:    .:.|:...|.|  :|::....:.:
Zfish   375 SEVKTVSPSDVLETTFTRKVGAFVNKATTQVT----TTGLDLPFAAFAPRSYDMEENDPMVHPPP 435

  Fly   368 SPIKSLLIPASATATYRHHSEPSLQPPPDDDNLLKELHFPFASPTSHVNDLAKFYRECYHAPPLK 432
            |||.|..:..|..:....||...    |:||.::.:....|:.......||..||||..:.|.|.
Zfish   436 SPIPSSPLQGSLHSNNSSHSGGQ----PNDDFVMVDFKPAFSKDDLLPMDLGTFYREFQNPPQLA 496

  Fly   433 GLNELQAEISSISSTPPASSGSGGVAACGPTAAATAIATSSADASAMDDLSRQLEQFETSLEDYD 497
            .|:   .::|:.|.                             |..:|.|..:|..:|.:::::|
Zfish   497 SLS---IDVSAQSM-----------------------------AEDLDSLPEKLAVYEKNIDEFD 529

  Fly   498 KLV 500
            ..|
Zfish   530 AFV 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atg13	NP_649796.1	ATG13	22..207	CDD:287051	85/191 (45%)
atg13	XP_005169027.1	ATG13	19..192	CDD:287051	87/195 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595010
Domainoid	1	1.000	91	1.000	Domainoid score	I7713
eggNOG	1	0.900	-	-		E1_KOG3874
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D395102at33208
OrthoFinder	1	1.000	-	-		FOG0004173
OrthoInspector	1	1.000	-	-		oto39657
orthoMCL	1	0.900	-	-		OOG6_107732
Panther	1	1.100	-	-	LDO	PTHR13430
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5992
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.710