Protein Alignment PNKP and TPP1

DIOPT Version :10

• Sequence 1: NP_649792.3
• Gene: PNKP / 40994
• FlyBaseID: FBgn0037578
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_013877.1
• Gene: TPP1 / 855188
• SGDID: S000004765
• Length: 238
• Species: Saccharomyces cerevisiae
• Alignment Length: 218
• Identity: 56/218 - (25%)
• Similarity: 85/218 - (38%)
• Gaps: 63/218 - (28%)

  Fly   166 IAGYDMDGTIIKTKS-GLVFPKNTDDWQII-FPEVPEKLKNL-----HKDGFKICLFTNQGGIA- 222
            :..:|:|.||||.|| .:.|.::..|||.| |......|..|     :.....|.:|:||||:.
Yeast    31 VYAFDLDHTIIKPKSPNISFSRSASDWQFINFNSKKSTLDYLCNIIDNDPTAVIVIFSNQGGVIT 95

  Fly   223 -----------RGKINL-------DDFKVKIKHIVAKLGVPIQ-----------VFIAIGDGF-- 256
                       ..||.|       |:....:.|.:.....|.:           .|.::|:.:
Yeast    96 VPRTSKSCTKYTNKILLFLKAIKNDERGETLSHRLWLYAAPKRPKTFAANHSKITFASLGESYNN 160

  Fly   257 -------YRKPLTGMWQHLKSEMNDGVEIQE-------DRCFFVGDAAGRPETGKGATKRRKDHS 307
                   .|||:|||.:..|.::.....:.|       :..::.|||||          |:||.|
Yeast   161 DPNIFEKVRKPMTGMVEFFKRDLESAYRVSEQISPIKLNWIYYCGDAAG----------RKKDFS 215

  Fly   308 LVDRLFAANVGISFYTPEVHFLG 330
            ..|..||.|:.:.|..||..|.|
Yeast   216 DSDIKFAENLHVEFKYPEEIFHG 238

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNKP	NP_649792.3	PNK-3'Pase	9..522	CDD:130724	56/218 (26%)
TPP1	NP_013877.1	Haloacid Dehalogenase-like Hydrolases	30..236	CDD:473868	54/214 (25%)