DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9601 and Aptx

DIOPT Version :9

Sequence 1:NP_649792.3 Gene:CG9601 / 40994 FlyBaseID:FBgn0037578 Length:523 Species:Drosophila melanogaster
Sequence 2:NP_079821.3 Gene:Aptx / 66408 MGIID:1913658 Length:342 Species:Mus musculus


Alignment Length:232 Identity:68/232 - (29%)
Similarity:108/232 - (46%) Gaps:46/232 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 RICTLKPTEPEHHSI---HLTAGENFVGRSRETGIRDSKCSKRQIQLQVDLKKAVVSLKVLGVNP 82
            |:|.|...:..|..|   ||.|  ..:|||.||.|.|.|||::|:||:.:..|..|.::.:||||
Mouse     9 RVCWLVRQDSRHQRIKLPHLEA--VVIGRSPETKITDKKCSRQQVQLKAECNKGYVKVQQMGVNP 71

  Fly    83 CGVNGLMLMQNGERELKHGDLVEIVYGRH----QFEVVFNPP---------PEYDKEKAEPLSTT 134
            ..::..::.::.|::|..|.::.:|.|.:    :||.|...|         .:.|.|:.|..|.|
Mouse    72 TSIDSGVIGKDQEKKLLPGQVLHMVNGLYPYIVEFEEVAESPNLTQRKRKRSDCDSEEMEAESGT 136

  Fly   135 -----LSPSE--KSERWDSSGNGK--LVIFTSVGVKGS---EKIAGY-DMDGTIIKTKSGLVFPK 186
                 .|||:  .|.:.|.:|..|  .:...|.|:|.|   .|:..| |....:||.|    :||
Mouse   137 GLAPGSSPSQCSVSPKKDKNGATKKESLGHWSQGLKMSMKDPKMQVYKDDQVVVIKDK----YPK 197

  Fly   187 NTDDW-----------QIIFPEVPEKLKNLHKDGFKI 212
            ....|           :::..|..|.||::|..|.|:
Mouse   198 ARHHWLVLPWASISSLKVVTSEHLELLKHMHAVGEKV 234

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9601NP_649792.3 PNK-3'Pase 9..522 CDD:130724 68/232 (29%)
FHA 26..115 CDD:238017 30/95 (32%)
HAD_like 170..288 CDD:119389 14/54 (26%)
NK 367..>440 CDD:302627
AptxNP_079821.3 Interactions with ADPRT/PARP1 and NCL. /evidence=ECO:0000250 1..102 32/94 (34%)
FHA 12..105 CDD:238017 30/94 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 114..170 13/55 (24%)
Nuclear localization signal. /evidence=ECO:0000250 118..122 0/3 (0%)
aprataxin_related 164..265 CDD:238609 20/75 (27%)
Interaction with DNA substrate. /evidence=ECO:0000250|UniProtKB:Q7Z2E3 193..197 1/7 (14%)
Interaction with DNA substrate. /evidence=ECO:0000250|UniProtKB:Q7Z2E3 255..256
Histidine triad motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00464 258..262
zf-C2HE 284..340 CDD:292895
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 59 1.000 Domainoid score I10628
eggNOG 1 0.900 - - E1_COG0241
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.810

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