Protein Alignment PNKP and Pnkp

DIOPT Version :10

• Sequence 1: NP_649792.3
• Gene: PNKP / 40994
• FlyBaseID: FBgn0037578
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: XP_006541101.2
• Gene: Pnkp / 59047
• MGIID: 1891698
• Length: 608
• Species: Mus musculus
• Alignment Length: 469
• Identity: 180/469 - (38%)
• Similarity: 266/469 - (56%)
• Gaps: 28/469 - (5%)

  Fly    44 VGRSRETGIRDSKCSKRQIQLQVDLKKAVVSLKVLGVNPCGVNGLMLMQNGERELKHGDLVEIVY 108
            :||...|.:.|.|||:.|::|..|.:...|::|.|||||..|....|.......|..||::.:|.
Mouse    47 LGRGPLTQVTDRKCSRNQVELIADPESRTVAVKQLGVNPSTVGVQELKPGLSGSLSLGDVLYLVN 111

  Fly   109 GRHQFEVVF----------NPPPEY--DKEKAEPLSTTLSPSEKSER-----WDSSGNGKLVIFT 156
            |.:...:.:          :.||:.  |.|:.|    ...|.:|..|     |:|.  .||::||
Mouse   112 GLYPLTLRWEELSTSGSQPDAPPDTPGDPEEGE----DTEPQKKRVRKSSLGWESL--KKLLVFT 170

  Fly   157 SVGVKGSEKIAGYDMDGTIIKTKSGLVFPKNTDDWQIIFPEVPEKLKNLHKDGFKICLFTNQGGI 221
            :.|||...|:|.:|:|||:|.|:||.|||.:..||:|::||:|:||:.|..:|:|:.:||||.||
Mouse   171 ASGVKPQGKVAAFDLDGTLITTRSGKVFPTSPSDWRILYPEIPKKLQELAAEGYKLVIFTNQMGI 235

  Fly   222 ARGKINLDDFKVKIKHIVAKLGVPIQVFIAIGDGFYRKPLTGMWQHLKSEMNDGVEIQEDRCFFV 286
            .|||:..:.||.|::.::.|||||.||.:|...|..|||::|||.||:.:.|:|:.|..:...||
Mouse   236 GRGKLPAEVFKGKVEAVLEKLGVPFQVLVATHAGLNRKPVSGMWDHLQEQANEGIPISVEDSVFV 300

  Fly   287 GDAAGR-PETGKGATKRRKDHSLVDRLFAANVGISFYTPEVHFLGKQVEQWNKPDFEPTSVQDQV 350
            |||||| .....|  :::||.|..|||||.|||:.|.|||..||.....::..|.|:|.::....
Mouse   301 GDAAGRLANWAPG--RKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPRTISSAG 363

  Fly   351 SLLDPDDLTLDDHPCEMVIMVGLPGSGKSHFCSSFFQPRGYKIVNADTLGSTQNCLTACKRFLDS 415
            .|..|:..:|.....|:|:.||.||:|||.|........||..||.|||||.|.|:::|:..|..
Mouse   364 PLYLPESSSLLSPNPEVVVAVGFPGAGKSTFIQEHLVSAGYVHVNRDTLGSWQRCVSSCQAALRQ 428

  Fly   416 GQSCVVDNTNVDAASRKKFLQLASEKMIPCRCLVMNVPVAQVKHNIAFRELSDSARTKIKDMVFN 480
            |:..|:||||.|..||.:::|.|.:..:||||......:.|.:||..|||::|.:...:.|||
Mouse   429 GKRVVIDNTNPDVPSRARYIQCAKDAGVPCRCFNFCATIEQARHNNRFREMTDPSHAPVSDMV-- 491

  Fly   481 MMKKKYQEPALDEG 494
            |...::....:.||
Mouse   492 MFSYRFGGSGVLEG 505

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNKP	NP_649792.3	PNK-3'Pase	9..522	CDD:130724	180/469 (38%)
Pnkp	XP_006541101.2	PNK-3'Pase	17..496	CDD:130724	178/458 (39%)