DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9601 and pnkp

DIOPT Version :9

Sequence 1:	NP_649792.3	Gene:	CG9601 / 40994	FlyBaseID:	FBgn0037578	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	XP_005173439.1	Gene:	pnkp / 569462	ZFINID:	ZDB-GENE-061013-433	Length:	588	Species:	Danio rerio

Alignment Length:	590	Identity:	209/590 - (35%)
Similarity:	303/590 - (51%)	Gaps:	102/590 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 CTLKPTEPEHHSIHLTAGENFV-GRSRETGIRDSKCSKRQIQLQVDLKKAVVSLKVLGVNPCGVN 86
            |||...:.:.  :.|..|...: ||..|:.|.|.|||:.|::|..|..|..|.:..||.||..::
Zfish     5 CTLVSVDGDR--VVLPDGRALMFGRGPESRISDKKCSRHQVKLVADYAKQEVLVTQLGPNPSSLD 67

  Fly    87 GLMLMQNGERELKHGDLVEIVYGRHQFEVVF--------NPPPEYDKEKAEPLSTTLSPSEKSER 143
            |..|.:.....|..|..:.:|...:.|.|.|        :..|    :|.|.::......:||.:
Zfish    68 GQCLGRGESGCLTTGQTLYLVNESYPFTVEFAFHCGIQLSSSP----QKKEKITNESKQRQKSSK 128

  Fly   144 WDSSGN----------------------------------------------------------- 149
             :|||:
Zfish   129 -ESSGSLKRNIHDYFSKSPKKAAKRPYSPEDDVPQPKRGREDEDNEDEGTSAEQKLQQLQAFAQS 192

  Fly   150 ----------------------GKLVIFTSVGVKGSEKIAGYDMDGTIIKTKSGLVFPKNTDDWQ 192
                                  |.|::||:.||..|.||||:|:||.||.||||.|||...|||:
Zfish   193 ESDNFKSSNPSSTCSQSHWQQIGSLMLFTAAGVTASSKIAGFDIDGCIITTKSGKVFPTGPDDWR 257

  Fly   193 IIFPEVPEKLKNLHKDGFKICLFTNQGGIARGKINLDDFKVKIKHIVAKLGVPIQVFIAIGDGFY 257
            |::||:..||.:|.|.|:|:..||||.||:|||:..:.||.|.:.|:..|.:|||||::...|.|
Zfish   258 ILYPEIQPKLASLLKKGYKVVFFTNQMGISRGKLRPEVFKSKAEDILQTLQLPIQVFVSTAPGIY 322

  Fly   258 RKPLTGMWQHLKSEMNDGVEIQEDRCFFVGDAAGRPETGKGATKRRKDHSLVDRLFAANVGISFY 322
            |||:.|||:||..:.|.||.:.....|:|||||||| ......|::||.|..|||||.|:|:.||
Zfish   323 RKPVIGMWEHLCEKANSGVMVDVSESFYVGDAAGRP-ANWAPGKKKKDFSCSDRLFALNIGLQFY 386

  Fly   323 TPEVHFLGKQVEQWNKPDFEPTSVQDQVSLLDPDDLTLDDHPCEMVIMVGLPGSGKSHFCSSFFQ 387
            |||.:|||.:...::.|:|:|..:..:..|.||.|.:|.....|:::.||.||:|||.|..:...
Zfish   387 TPEEYFLGWKPATFSFPEFDPRKLDSKARLYDPPDASLTSTKQEIIVAVGFPGAGKSTFFQTHII 451

  Fly   388 PRGYKIVNADTLGSTQNCLTACKRFLDSGQSCVVDNTNVDAASRKKFLQLASEKMIPCRCLVMNV 452
            |:||..||.||:||.|:|::||:|.|..|:|..|||||.|..|||:::.:|....:.|||.....
Zfish   452 PKGYAYVNRDTMGSWQHCVSACERALKEGKSVAVDNTNPDLESRKRYIDVAQSAGVSCRCFNFTA 516

  Fly   453 PVAQVKHNIAFRELSDSARTK---IKDMVFNMMKKKYQEPALDEGFISIHKVNFKPNFADEKQEK 514
            .:.|.|||..|||:..|| ||   :.|||.:..|||:..|:|.|||..:.:::|.|:|:|::.|.
Zfish   517 SLDQAKHNNRFREMVPSA-TKHVPVNDMVIHSYKKKFVVPSLSEGFSEVLQIHFVPSFSDKRSEF 580

  Fly   515 LYKMY 519
            |:|.:
Zfish   581 LFKQF 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9601	NP_649792.3	PNK-3'Pase	9..522	CDD:130724	209/590 (35%)
		FHA	26..115	CDD:238017	25/89 (28%)
		HAD_like	170..288	CDD:119389	58/117 (50%)
		NK	367..>440	CDD:302627	35/72 (49%)
pnkp	XP_005173439.1	PNK-3'Pase	1..588	CDD:130724	209/590 (35%)
		FHA	5..97	CDD:238017	28/93 (30%)
		HAD_like	234..353	CDD:119389	58/118 (49%)
		NK	431..>534	CDD:302627	45/102 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580444
Domainoid	1	1.000	180	1.000	Domainoid score	I3464
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5247
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2313
OMA	1	1.010	-	-		QHG54768
OrthoDB	1	1.010	-	-		D1252087at2759
OrthoFinder	1	1.000	-	-		FOG0004625
OrthoInspector	1	1.000	-	-		oto40398
orthoMCL	1	0.900	-	-		OOG6_102580
Panther	1	1.100	-	-	LDO	PTHR12083
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R942
SonicParanoid	1	1.000	-	-		X3825
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940