Protein Alignment PNKP and aptx

DIOPT Version :10

• Sequence 1: NP_649792.3
• Gene: PNKP / 40994
• FlyBaseID: FBgn0037578
• Length: 523
• Species: Drosophila melanogaster
• Sequence 2: NP_991394.1
• Gene: aptx / 403092
• XenbaseID: XB-GENE-1015068
• Length: 347
• Species: Xenopus tropicalis
• Alignment Length: 253
• Identity: 62/253 - (24%)
• Similarity: 98/253 - (38%)
• Gaps: 80/253 - (31%)

  Fly    23 CTLKPTEPEHHSIHLTAGENFV-GRSRETGIRDSKCSKRQIQLQVDLKKAVVSLKVLGVNPCGVN 86
            |.|...:.:|..|.|...|..| ||..||.|.|.|||:.|:||..|..|..|.:|.||.||..::
 Frog     4 CWLVSKDGKHGRIRLPHAETVVIGRGPETQITDKKCSRHQVQLMADCNKGYVKVKQLGTNPTSID 68

  Fly    87 GLMLMQNGERELKHGDLVEIVYGRHQFEVVF-----NPPPEYDKE-------------------- 126
            |:.:.:..:.:||.|..:.||...:.:.:.|     ||..:.:.|
 Frog    69 GVDIGKEQKVDLKPGHTLHIVNNLYPYVIEFLEGATNPHAKRENENRSSSKRTQENSLNEGTGTS 133

  Fly   127 -KAEPLSTTLSPSEKS---------ERWD-----SSGNGKLVIFTSVGVKGS-----------EK 165
             |.....:.:|||..|         |:::     |.|:      .|.|:|.|           :|
 Frog   134 MKLMKKESNISPSSSSGKNSSCSTEEKYNAQEVKSQGH------WSQGLKASMQDPTMQVFKDDK 192

  Fly   166 IAGYDMDGTIIKTKSGLVFPKNTDDW-----------QIIFPEVPEKLKNLHKDGFKI 212
            :       .:||.|    :||....|           :::..|..|.::::|..|.||
 Frog   193 V-------VVIKDK----YPKARYHWLVLPWQSIANLKVLRAEHLELVQHMHAVGQKI 239

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PNKP	NP_649792.3	PNK-3'Pase	9..522	CDD:130724	62/253 (25%)
aptx	NP_991394.1	FHA_APTX	3..101	CDD:438787	34/96 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	107..176		10/74 (14%)
		aprataxin_related	169..270	CDD:238609	18/88 (20%)
		Interaction with DNA substrate. /evidence=ECO:0000250|UniProtKB:Q7Z2E3	198..202		1/7 (14%)
		Interaction with DNA substrate. /evidence=ECO:0000250|UniProtKB:Q7Z2E3	260..261
		Histidine triad motif	263..267
		zf-C2HE	288..345	CDD:465082