DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG9601 and Pnkp

DIOPT Version :9

Sequence 1:	NP_649792.3	Gene:	CG9601 / 40994	FlyBaseID:	FBgn0037578	Length:	523	Species:	Drosophila melanogaster
Sequence 2:	NP_001004259.1	Gene:	Pnkp / 308576	RGDID:	1303331	Length:	522	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	191/490 - (38%)
Similarity:	281/490 - (57%)	Gaps:	23/490 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 VGRSRETGIRDSKCSKRQIQLQVDLKKAVVSLKVLGVNPCGVNGLMLMQNGERELKHGDLVEIVY 108
            :||...|.:.|.|||:.|::|..|.:...|::|.|||||..|....|.......|..||::.:|.
  Rat    33 LGRGPLTQVMDRKCSRNQVELIADPETRTVAVKQLGVNPSTVGVQELKPGVSGSLSVGDVLYLVN 97

  Fly   109 GRH----QFEVVFNP--PPE------YDKEK---AEPLSTTLSPSEKSERWDSSGNGKLVIFTSV 158
            |.:    ::|.:..|  ||:      .|.|:   .||....:..|  |..|:|.  .:|::||:.
  Rat    98 GLYPLTLRWEEISTPGSPPDTPPGNPVDPEEGKDTEPQKKRMRKS--SPGWESF--KQLLVFTAS 158

  Fly   159 GVKGSEKIAGYDMDGTIIKTKSGLVFPKNTDDWQIIFPEVPEKLKNLHKDGFKICLFTNQGGIAR 223
            |||...|:|.:|:|||:|.|:||.|||.:..||:|::||:|:||:.|..:|:|:.:.|||.||.|
  Rat   159 GVKPRGKVAAFDLDGTLITTRSGKVFPTSPSDWRILYPEIPKKLQELAAEGYKLVILTNQMGIGR 223

  Fly   224 GKINLDDFKVKIKHIVAKLGVPIQVFIAIGDGFYRKPLTGMWQHLKSEMNDGVEIQEDRCFFVGD 288
            ||:..:.||.|::.::.|||||.||.:|...|..|||::|||.||:.:.|:|:.|......||||
  Rat   224 GKLPAEVFKAKVEAVLEKLGVPFQVLVATHAGLNRKPVSGMWDHLQEKGNEGIPISIGDSVFVGD 288

  Fly   289 AAGRPETGKGATKRRKDHSLVDRLFAANVGISFYTPEVHFLGKQVEQWNKPDFEPTSVQDQVSLL 353
            ||||| ......|::||.|..|||||.|||:.|.|||..||.....::..|.|:|.::.....|.
  Rat   289 AAGRP-ANWAPGKKKKDFSCADRLFALNVGLPFATPEEFFLKWPAARFELPAFDPRTISSAGPLY 352

  Fly   354 DPD-DLTLDDHPCEMVIMVGLPGSGKSHFCSSFFQPRGYKIVNADTLGSTQNCLTACKRFLDSGQ 417
            .|: ...|..:| |:|:.||.||:|||.|........||..||.|||||.|.|:.:|:..|..|:
  Rat   353 LPESSFLLSPNP-EVVVAVGFPGAGKSTFIQKHLVSAGYVHVNRDTLGSWQRCVNSCQAALRQGK 416

  Fly   418 SCVVDNTNVDAASRKKFLQLASEKMIPCRCLVMNVPVAQVKHNIAFRELSDSARTKIKDMVFNMM 482
            ..|:||||.|..||.:::|.|.:..:||||......:.|.:||..|||::|.:...:.|||....
  Rat   417 QVVIDNTNPDIQSRARYIQCAKDAGVPCRCFSFCATIEQARHNNRFREMTDPSHAPVSDMVMFSY 481

  Fly   483 KKKYQEPALDEGFISIHKVNFK-PNFADEKQEKLY 516
            :|:::.|.|.|||:.|.:|.|: ....|...::||
  Rat   482 RKQFEPPTLAEGFLEILQVPFRLQEHLDPALQRLY 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9601	NP_649792.3	PNK-3'Pase	9..522	CDD:130724	191/490 (39%)
		FHA	26..115	CDD:238017	24/74 (32%)
		HAD_like	170..288	CDD:119389	55/117 (47%)
		NK	367..>440	CDD:302627	33/72 (46%)
Pnkp	NP_001004259.1	PNK-3'Pase	3..522	CDD:130724	191/490 (39%)
		HAD_like	168..288	CDD:119389	55/119 (46%)
		NK	366..>442	CDD:302627	33/75 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340639
Domainoid	1	1.000	173	1.000	Domainoid score	I3602
eggNOG	1	0.900	-	-		E1_COG0241
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5247
Inparanoid	1	1.050	327	1.000	Inparanoid score	I2388
OMA	1	1.010	-	-		QHG54768
OrthoDB	1	1.010	-	-		D1252087at2759
OrthoFinder	1	1.000	-	-		FOG0004625
OrthoInspector	1	1.000	-	-		oto96652
orthoMCL	1	0.900	-	-		OOG6_102580
Panther	1	1.100	-	-	LDO	PTHR12083
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3825
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.770