DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Arl2 and trim23

DIOPT Version :9

Sequence 1:	NP_476886.1	Gene:	Arl2 / 40993	FlyBaseID:	FBgn0004908	Length:	184	Species:	Drosophila melanogaster
Sequence 2:	XP_005155659.1	Gene:	trim23 / 767706	ZFINID:	ZDB-GENE-060929-804	Length:	576	Species:	Danio rerio

Alignment Length:	171	Identity:	68/171 - (39%)
Similarity:	99/171 - (57%)	Gaps:	9/171 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EMRILLLGLDNAGKTTILKRFNGEPIDTISPTLGFNIKTLEHNGYTLNMWDVGGQKSLRSYWRNY 80
            |:|::.||||.|||||||.:...:......||:|||::|:|:......:|||||:..||..|::|
Zfish   406 EIRVVTLGLDGAGKTTILFKLKQDEFMQPIPTIGFNVETVEYKNLKFTIWDVGGKHKLRPLWKHY 470

  Fly    81 FESTDGLVWVVDSADRMRLESCGQELQVLLQEERLAGATLLVLCNKQDLPGALSSNEIKEILHLE 145
            :.:|..:|:|:||..|.||.....||..||.|:.|..|.||:..||||:|||:|..|:.|:|.|.
Zfish   471 YLNTQAVVFVIDSCHRDRLMESHSELAKLLTEKELRDALLLIFANKQDVPGAVSVEEMTELLSLH 535

  Fly   146 DITT-HHWLVAGVSAVTGEKLLSSMDWL--------IADIA 177
            .:.. ..|.:.|..|.:|..|...:|||        :.|:|
Zfish   536 KLCCGRSWHIQGCDARSGMGLHEGLDWLSRQLVAAGVLDVA 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Arl2	NP_476886.1	Arl2	3..175	CDD:206720	66/167 (40%)
trim23	XP_005155659.1	RING	33..76	CDD:214546
		BBOX	127..170	CDD:237988
		BBOX	175..221	CDD:197662
		iSH2_PI3K_IA_R	228..372	CDD:304922
		ARD1	408..576	CDD:206723	66/167 (40%)
		Ras	408..567	CDD:278499	65/158 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910